» Articles » PMID: 31475470

Combination Therapy Using Non-ablative Fractional Laser and Intralesional Triamcinolone Injection for Hypertrophic Scars and Keloids Treatment

Overview
Journal Int Wound J
Date 2019 Sep 3
PMID 31475470
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Combinations of various treatment modalities were shown to be more effective than monotherapy when treating hypertrophic scars and keloids. This study was conducted to assess the effectiveness of combination therapy with non-ablative fractional laser and intralesional steroid injection. From May 2015 to June 2017, a total of 38 patients with hypertrophic scars or keloids were evaluated. The control group of 21 patients received steroid injection alone, and 17 patients (the combined group) received 1550-nm erbium-glass fractional laser treatment and steroid injection simultaneously. The mean number of treatment sessions was statistically fewer in the combined group than in the control group (6.95 vs 5.47, P = .042). There was a significant difference in the patient's scale in the combined group (14.62 vs 22.82, P = .005); however, the observer's scale was not significantly different (17.92 vs 20.55, P = .549). The recurrence rate was 38.1% (8/21) in the control group and 35.3% (6/17) in the combined groups and showed no significant difference (P = .859). However, the mean remission period was statistically longer in the combined group (3.00 months vs 4.17 months, P = .042). Combination therapy with non-ablative fractional laser and intralesional steroid injection showed better results for the treatment of hypertrophic scars and keloids with fewer treatment sessions, better patient satisfaction, and longer remission periods.

Citing Articles

Evaluating the effectiveness and safety of pulsed dye laser alone, the combination of pulsed dye laser and botulinum toxin type A, and the combination of pulsed dye laser and triamcinolone injection in the treatment of hypertrophic and keloid scars:....

Atefi N, Jafari M, Roohaninasab M, Dehghani A, Jafarzadeh A, Peighambari S Lasers Med Sci. 2025; 40(1):92.

PMID: 39953344 DOI: 10.1007/s10103-025-04338-6.


Efficacy of Nd:YAG Laser and Intralesional Triamcinolone Injection Combination Therapy in the Postoperative Management of Keloids.

Park J, Jeong J, Park J Aesthetic Plast Surg. 2024; 49(2):576-583.

PMID: 39373734 PMC: 11814004. DOI: 10.1007/s00266-024-04433-z.


The efficacy, satisfaction, and safety of carbon dioxide (CO2) fractional laser in combination with pulsed dye laser (PDL) versus each one alone in the treatment of hypertrophic burn scars: a single-blinded randomized controlled trial.

Kivi M, Jafarzadeh A, Hosseini-Baharanchi F, Salehi S, Goodarzi A Lasers Med Sci. 2024; 39(1):69.

PMID: 38376542 DOI: 10.1007/s10103-024-03976-6.


Efficacy of fractional CO laser in combination with stromal vascular fraction (SVF) compared with fractional CO laser alone in the treatment of burn scars: a randomized controlled clinical trial.

Roohaninasab M, Khodadad F, Sadeghzadeh-Bazargan A, Atefi N, Zare S, Jafarzadeh A Stem Cell Res Ther. 2023; 14(1):269.

PMID: 37742019 PMC: 10518108. DOI: 10.1186/s13287-023-03480-8.


Advances in Photoelectric Therapy for the Early Intervention and Treatment of Traumatic Scars.

Tian Q, Zhang Y, Wang J, Huang G Clin Cosmet Investig Dermatol. 2023; 16:869-877.

PMID: 37038450 PMC: 10082596. DOI: 10.2147/CCID.S407361.


References
1.
Roberts W . Skin type classification systems old and new. Dermatol Clin. 2009; 27(4):529-33, viii. DOI: 10.1016/j.det.2009.08.006. View

2.
Ryu H, Cho J, Lee K, Cho J . Prevention of thyroidectomy scars in Korean patients using a new combination of intralesional injection of low-dose steroid and pulsed dye laser starting within 4 weeks of suture removal. Dermatol Surg. 2014; 40(5):562-8. DOI: 10.1111/dsu.12472. View

3.
Niwa A, Mello A, Torezan L, Osorio N . Fractional photothermolysis for the treatment of hypertrophic scars: clinical experience of eight cases. Dermatol Surg. 2009; 35(5):773-7. DOI: 10.1111/j.1524-4725.2009.01127.x. View

4.
Behera B, Kumari R, Thappa D, Malathi M . Therapeutic Efficacy of Intralesional Steroid With Carbon Dioxide Laser Versus With Cryotherapy in Treatment of Keloids: A Randomized Controlled Trial. Dermatol Surg. 2016; 42(10):1188-98. DOI: 10.1097/DSS.0000000000000873. View

5.
Sachdeva S . Nonablative fractional laser resurfacing in Asian skin--a review. J Cosmet Dermatol. 2010; 9(4):307-12. DOI: 10.1111/j.1473-2165.2010.00528.x. View