Safety and Clinical Outcomes of Endoscopic Ultrasound-guided Gallbladder Drainage with Lumen-apposing Metal Stents in Patients with Dwell Time over One Year

Overview

Journal Ann Gastroenterol

Specialty Gastroenterology

Date 2019 Sep 3

PMID 31474799

Citations 10

Authors

Raul Torres Yuste

Francisco Javier Garcia-Alonso

Ramon Sanchez-Ocana

Marta Cimavilla

Irene Penas Herrero

Ana Yaiza Carbajo

Marina de Benito Sanz

Carlos de la Serna Higuera

Manuel Perez-Miranda

Affiliations

Soon will be listed here.

Abstract

Background: Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has proved effective in patients with cholecystitis at high surgical risk. The long-term risks of gallstone-related disease and stent-related adverse events are unknown.

Methods: We performed a retrospective evaluation of a case series including subjects who underwent EUS-GBD using lumen-apposing metal stents (LAMS). Patients were identified from a prospective LAMS registry at a single tertiary center. Patients with a stent indwell time <1 year were excluded. Data regarding stent deployment and adverse events were retrieved from the prospective LAMS registry, while emergency room visits, admissions and causes of death were retrieved from electronic medical records.

Results: We included 22 patients with a median age of 88.3 years (interquartile range [IQR]: 82.6-92.7), 14 (63.6%) were male. Median follow up was 24.4 months (IQR: 18.2-42.4) and median time to the last available imaging procedure was 607 days (IQR: 463-938). No LAMS-related adverse events were identified beyond the first year of follow up. During follow up, 12 patients (54.5%) visited the emergency room 34 times (1 visit/patient, IQR: 0-3) and a total of 36 hospital admissions were required, with a median of 1 admission/patient (IQR: 0-3). Fourteen (63.6%) patients died during follow up. Only 1 patient (4.5%) required new hospital admissions for gallstone-related disease.

Conclusions: There were no adverse events beyond the first year after stent deployment, with only 4.5% of subjects requiring gallstone-related admissions. Permanent EUS-GBD with LAMS may be a definitive treatment for acute cholecystitis in patients ineligible for cholecystectomy.

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