Myocardial Extracellular Volume Quantification in Cardiac CT: Comparison of the Effects of Two Different Iterative Reconstruction Algorithms with MRI As a Reference Standard

Overview

Journal Eur Radiol

Specialty Radiology

Date 2019 Sep 1

PMID 31471751

Citations 9

Authors

Takafumi Emoto

Masafumi Kidoh

Seitaro Oda

Takeshi Nakaura

Yasunori Nagayama

Akira Sasao

Yoshinori Funama

Satoshi Araki

Seiji Takashio

Kenji Sakamoto

Eiichiro Yamamoto

Koichi Kaikita

Kenichi Tsujita

Yasuyuki Yamashita

Affiliations

Soon will be listed here.

Abstract

Objectives: To compare the effects of hybrid iterative reconstruction (HIR) and model-based iterative reconstruction (MBIR) that incorporates a beam-hardening model for myocardial extracellular volume (ECV) quantification by cardiac CT using MRI as a reference standard.

Methods: In this retrospective study, a total of 34 patients were evaluated using cardiac CT and MRI. Paired CT image sets were created using HIR and MBIR with a beam-hardening model. We calculated mean absolute differences and correlations between the global mid-ventricular ECV derived from CT and MRI via Pearson correlation analysis. In addition, we performed qualitative analysis of image noise and beam-hardening artifacts on postcontrast images using a four-point scale: 1 = extensive, 2 = strong, 3 = mild, and 4 = minimal.

Results: The mean absolute difference between the ECV derived from CT and MRI for MBIR was significantly smaller than that for HIR (MBIR 3.74 ± 3.59%; HIR 4.95 ± 3.48%, p = 0.034). MBIR improved the correlation between the ECV derived from CT and MRI when compared with HIR (MBIR, r = 0.60, p < 0.001; HIR, r = 0.47, p = 0.006). In qualitative analysis, MBIR significantly reduced image noise and beam-hardening artifacts when compared with HIR ([image noise, MBIR 3.4 ± 0.7; HIR 2.1 ± 0.8, p < 0.001], [beam-hardening artifacts, MBIR 3.8 ± 0.4; HIR 2.6 ± 1.0, p < 0.001]).

Conclusions: MBIR with a beam-hardening model effectively reduced image noise and beam-hardening artifacts and improved myocardial ECV quantification when compared with HIR using MRI as a reference standard.

Key Points: • MBIR with a beam-hardening model effectively reduced image noise and beam-hardening artifacts. • The mean absolute difference between the global mid-ventricular ECV derived from CT and MRI for MBIR was significantly smaller than that for conventional HIR. • MBIR provided more accurate myocardial CT number and improved ECV quantification when compared with HIR.

Citing Articles

Diagnostic performance of unenhanced electrocardiogram-gated cardiac CT for detecting myocardial edema.

Emoto T, Kidoh M, Oda S, Sakabe D, Morita K, Hatemura M Medicine (Baltimore). 2024; 103(20):e38295.

PMID: 38758838 PMC: 11098205. DOI: 10.1097/MD.0000000000038295.

Myocardial extracellular volume quantification in cardiac amyloidosis: a comparative study between cardiac computed tomography and magnetic resonance imaging.

Hayashi H, Oda S, Kidoh M, Yamaguchi S, Yoshimura F, Takashio S Eur Radiol. 2023; 34(2):1016-1025.

PMID: 37597032 DOI: 10.1007/s00330-023-10129-w.

CT for the evaluation of myocardial extracellular volume with MRI as reference: a systematic review and meta-analysis.

Zhang H, Guo H, Liu G, Wu C, Ma Y, Li S Eur Radiol. 2023; 33(12):8464-8476.

PMID: 37378712 DOI: 10.1007/s00330-023-09872-x.

Cardiac computed tomography-derived myocardial tissue characterization after anthracycline treatment.

Egashira K, Sueta D, Kidoh M, Tomiguchi M, Oda S, Usuku H ESC Heart Fail. 2022; 9(3):1792-1800.

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Measurement of myocardial extracellular volume using cardiac dual-energy computed tomography in patients with ischaemic cardiomyopathy: a comparison of different methods.

Shao J, Jiang J, Wang X, Wu S, Xiao J, Zheng K Int J Cardiovasc Imaging. 2022; 38(7):1591-1600.

PMID: 35201509 DOI: 10.1007/s10554-022-02532-z.

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