A Toxicological Evaluation of Mango Leaf Extract () Containing 60% Mangiferin

Overview

Journal J Toxicol

Publisher Wiley

Specialty Toxicology

Date 2019 Aug 31

PMID 31467524

Citations 12

Authors

Robin A Reddeman

Robert Glavits

John R Endres

Amy E Clewell

Gabor Hirka

Adel Vertesi

Erzsebet Beres

Ilona Pasics Szakonyine

Affiliations

Soon will be listed here.

Abstract

A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract () containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.

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References

Araujo M, Antunes L, Takahashi C . Protective effect of thiourea, a hydroxyl-radical scavenger, on curcumin-induced chromosomal aberrations in an in vitro mammalian cell system. Teratog Carcinog Mutagen. 2001; 21(2):175-80. DOI: 10.1002/1520-6866(2001)21:2<175::aid-tcm6>3.0.co;2-v. View

Rodeiro I, Cancino L, Gonzalez J, Morffi J, Garrido G, Gonzalez R . Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. Food Chem Toxicol. 2006; 44(10):1707-13. DOI: 10.1016/j.fct.2006.05.009. View

Gonzalez J, Rodriguez M, Rodeiro I, Morffi J, Guerra E, Leal F . Lack of in vivo embryotoxic and genotoxic activities of orally administered stem bark aqueous extract of Mangifera indica L. (Vimang). Food Chem Toxicol. 2007; 45(12):2526-32. DOI: 10.1016/j.fct.2007.05.029. View

Garrido G, Rodeiro I, Hernandez I, Garcia G, Perez G, Merino N . In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang). Drug Chem Toxicol. 2009; 32(1):53-8. DOI: 10.1080/01480540802432551. View

Shah K, Patel M, Patel R, Parmar P . Mangifera indica (mango). Pharmacogn Rev. 2012; 4(7):42-8. PMC: 3249901. DOI: 10.4103/0973-7847.65325. View

Rodeiro I, Hernandez S, Morffi J, Herrera J, Gomez-Lechon M, Delgado R . Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract. Food Chem Toxicol. 2012; 50(9):3360-6. DOI: 10.1016/j.fct.2012.06.032. View

Zhang Y, Li J, Wu Z, Liu E, Shi P, Han L . Acute and long-term toxicity of mango leaves extract in mice and rats. Evid Based Complement Alternat Med. 2014; 2014:691574. PMC: 4163298. DOI: 10.1155/2014/691574. View

Clewell A, Beres E, Vertesi A, Glavits R, Hirka G, Endres J . A Comprehensive Toxicological Safety Assessment of an Extract of Olea Europaea L. Leaves (Bonolive™). Int J Toxicol. 2015; 35(2):208-21. DOI: 10.1177/1091581815619764. View

Bhatt L, Sebastian B, Joshi V . Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity. J Ayurveda Integr Med. 2017; 8(2):62-67. PMC: 5496998. DOI: 10.1016/j.jaim.2017.04.006. View

10.

Reddeman R, Glavits R, Endres J, Murbach T, Hirka G, Vertesi A . A Toxicological Assessment of Creatyl-l-Leucine. Int J Toxicol. 2018; 37(2):171-187. DOI: 10.1177/1091581817751142. View

11.

Marx T, Reddeman R, Clewell A, Endres J, Beres E, Vertesi A . An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. J Toxicol. 2018; 2018:8143582. PMC: 6011091. DOI: 10.1155/2018/8143582. View

12.

Matsushima T, Araki A, Yagame O, Muramatsu M, Koyama K, Ohsawa K . Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637. Mutat Res. 1985; 150(1-2):141-6. DOI: 10.1016/0027-5107(85)90111-3. View

13.

Irwin S . Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia. 1968; 13(3):222-57. DOI: 10.1007/BF00401402. View

14.

Savage J . Classification and relationships of induced chromosomal structual changes. J Med Genet. 1976; 13(2):103-22. PMC: 1013369. DOI: 10.1136/jmg.13.2.103. View

15.

Decker E . Phenolics: prooxidants or antioxidants?. Nutr Rev. 1998; 55(11 Pt 1):396-8. DOI: 10.1111/j.1753-4887.1997.tb01580.x. View