Viral Priming of Cell Intrinsic Innate Antiviral Signaling by the Unfolded Protein Response

Overview

Journal Nat Commun

Specialty Biology

Date 2019 Aug 31

PMID 31467282

Citations 32

Authors

Tea Carletti

Mohammad Khalid Zakaria

Valentina Faoro

Laura Reale

Yvette Kazungu

Danilo Licastro

Alessandro Marcello

Affiliations

Soon will be listed here.

Abstract

The innate response to a pathogen is critical in determining the outcome of the infection. However, the interplay of different cellular responses that are activated following viral infection and their contribution to innate antiviral signalling has not been clearly established. This work shows that flaviviruses, including Dengue, Zika, West Nile and Tick-borne encephalitis viruses, activate the unfolded protein response before transcription of interferon regulatory factor 3 induced genes. Infection in conditions of unfolded protein response priming leads to early activation of innate antiviral responses and cell intrinsic inhibition of viral replication, which is interferon regulatory factor 3 dependent. These results demonstrate that the unfolded protein response is not only a physiological reaction of the cell to viral infection, but also synergizes with pattern recognition sensing to mount a potent antiviral response.

Citing Articles

Dynamic Modulation of IRE1α-XBP1 Signaling by Adenovirus.

Jang Y, Bunz F Pathogens. 2025; 14(2).

PMID: 40005508 PMC: 11857978. DOI: 10.3390/pathogens14020132.

Transmission of unfolded protein response-a regulator of disease progression, severity, and spread in virus infections.

Prasad V mBio. 2025; 16(2):e0352224.

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Endoplasmic reticulum stress triggers unfolded protein response as an antiviral strategy of teleost erythrocytes.

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Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection.

Sui L, Wang W, Guo X, Zhao Y, Tian T, Zhang J Nat Commun. 2024; 15(1):10435.

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