Cuprous Binding Promotes Interaction of Copper Transport Protein HCTR1 with Cell Membranes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Aug 29

PMID 31461100

Citations 7

Authors

Yang Yang

Yang Zhu

Hongze Hu

Lanjun Cheng

Manman Liu

Guolin Ma

Siming Yuan

Peixin Cui

Yangzhong Liu

Affiliations

Soon will be listed here.

Abstract

Cu(i) binds to the N-terminal metal binding domain (MBD) of hCTR1 and induces its conformational change, which promotes the interaction of the MBD with cell membranes. The membrane interaction was confirmed in living cells. This process could be the first step to initiate the cellular uptake of copper ions by hCTR1.

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