Practical Method for Preparation of ()-2-Amino-5,5,5-trifluoropentanoic Acid Via Dynamic Kinetic Resolution

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2019 Aug 29

PMID 31460294

Citations 3

Authors

Haibo Mei

Jianlin Han

Ryosuke Takeda

Tsubasa Sakamoto

Toshio Miwa

Yutaka Minamitsuji

Hiroki Moriwaki

Hidenori Abe

Vadim A Soloshonok

Affiliations

Soon will be listed here.

Abstract

This work reports an operationally convenient ∼20 g scale synthesis of ()-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.

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Asymmetric Synthesis of 4,4-(Difluoro)glutamic Acid via Chiral Ni(II)-Complexes of Dehydroalanine Schiff Bases. Effect of the Chiral Ligands Structure on the Stereochemical Outcome.

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Preparative Method for Asymmetric Synthesis of ()-2-Amino-4,4,4-trifluorobutanoic Acid.

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