Co(III)-Catalyzed C-H Activation: A Site-Selective Conjugate Addition of Maleimide to Indole at the C-2 Position

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2019 Aug 29

PMID 31457739

Citations 2

Authors

Nachimuthu Muniraj

Kandikere Ramaiah Prabhu

Affiliations

Soon will be listed here.

Abstract

The cobalt(III)-catalyzed site-selective C-2 functionalization of indole has been developed using the pyrimidinyl group as a directing group. This reaction furnishes 3-arylated succinimide derivatives in excellent yields in a shorter duration using an inexpensive Co catalyst. Highly selective C-2 functionalization of indoles was achieved in the presence of the highly reactive C-3 position. This protocol is compatible with a variety of -pyrimidinyl indole and maleimide derivatives, and it can be easily scaled-up. This method is also applicable for maleic ester and heteroarenes.

Citing Articles

Cp*Co(III)-Catalyzed C-H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool.

Carral-Menoyo A, Sotomayor N, Lete E ACS Omega. 2020; 5(39):24974-24993.

PMID: 33043175 PMC: 7542607. DOI: 10.1021/acsomega.0c03639.

Hydroarylations by cobalt-catalyzed C-H activation.

Santhoshkumar R, Cheng C Beilstein J Org Chem. 2018; 14:2266-2288.

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