BK () Channel Regulates Mitochondrial Function and Lifespan in

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 Aug 24

PMID 31438578

Citations 15

Authors

Shubha Gururaja Rao

Piotr Bednarczyk

Atif Towheed

Kajol Shah

Priyanka Karekar

Devasena Ponnalagu

Haley N Jensen

Sankar Addya

Beverly A S Reyes

Elisabeth J Van Bockstaele

Adam Szewczyk

Douglas C Wallace

Harpreet Singh

Affiliations

Soon will be listed here.

Abstract

BK channels, originally discovered in as (), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BK channels in cellular and organ protection possibly for their ability to modulate mitochondrial function. However, the direct role of BK channels in regulating mitochondrial structure and function is not deciphered. Here, we demonstrate that BK channels are present in fly mitochondria, and mutants show structural and functional defects in mitochondria. mutants display an increase in reactive oxygen species and the modulation of ROS affected their survival. We also found that the absence of BK channels reduced the lifespan of , and overexpression of human BK channels in flies extends life span in males. Our study establishes the presence of BK channels in mitochondria of and ascertains its novel physiological role in regulating mitochondrial structural and functional integrity, and lifespan.

Citing Articles

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity.

Sanghvi S, Sridharan D, Evans P, Dougherty J, Szteyn K, Gabrilovich D Nat Commun. 2025; 16(1):42.

PMID: 39747826 PMC: 11697022. DOI: 10.1038/s41467-024-55379-4.

Understanding mitochondrial potassium channels: 33 years after discovery.

Szewczyk A Acta Biochim Pol. 2024; 71:13126.

PMID: 38863652 PMC: 11165062. DOI: 10.3389/abp.2024.13126.

Redox Regulation of Mitochondrial Potassium Channels Activity.

Lewandowska J, Kalenik B, Wrzosek A, Szewczyk A Antioxidants (Basel). 2024; 13(4).

PMID: 38671882 PMC: 11047711. DOI: 10.3390/antiox13040434.

Chloride ions in health and disease.

Raut S, Singh K, Sanghvi S, Loyo-Celis V, Varghese L, Singh E Biosci Rep. 2024; 44(5).

PMID: 38573803 PMC: 11065649. DOI: 10.1042/BSR20240029.

The BK (slo) channel regulates the cardiac function of Drosophila.

Gururaja Rao S, Lam A, Seeley S, Park J, Aruva S, Singh H Physiol Rep. 2024; 12(7):e15996.

PMID: 38561252 PMC: 10984821. DOI: 10.14814/phy2.15996.

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