Meal Against Diabetic Neuropathic Pain: An HS-Mediated Effect of Glucoerucin

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Aug 22

PMID 31430978

Citations 14

Authors

Elena Lucarini

Eleonora Pagnotta

Laura Micheli

Carmen Parisio

Lara Testai

Alma Martelli

Vincenzo Calderone

Roberto Matteo

Luca Lazzeri

Lorenzo Di Cesare Mannelli

Carla Ghelardini

Affiliations

Soon will be listed here.

Abstract

The management of pain in patients affected by diabetic neuropathy still represents an unmet therapeutic need. Recent data highlighted the pain-relieving efficacy of glucosinolates deriving from Brassicaceae. The purpose of this study was to evaluate the anti-hyperalgesic efficacy of Eruca sativa defatted seed meal, along with its main glucosinolate, glucoerucin (GER), on diabetic neuropathic pain induced in mice by streptozotocin (STZ). The mechanism of action was also investigated. Hypersensitivity was assessed by paw pressure and cold plate tests after the acute administration of the compounds. Once bio-activated by myrosinase, both E. sativa defatted meal (1 g kg p.o.) and GER (100 µmol kg p.o., equimolar to meal content) showed a dose-dependent pain-relieving effect in STZ-diabetic mice, but the meal was more effective than the glucosinolate. The co-administration with HS scavengers abolished the pain relief mediated by both meal and GER. Their effect was also prevented by selectively blocking Kv7 potassium channels. Repeated treatments with E. sativa meal did not induce tolerance to the anti-hypersensitive effect. In conclusion, meal can be suggested as a new nutraceutical tool for pain relief in patients with diabetic neuropathy.

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