The Efficacy of Defatted Seed Meal Against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief

Overview

Journal Nutrients

Date 2022 Aug 12

PMID 35956313

Authors

Elena Lucarini

Laura Micheli

Eleonora Pagnotta

Alessandra Toti

Valentina Ferrara

Clara Ciampi

Francesco Margiotta

Alma Martelli

Lara Testai

Vincenzo Calderone

Roberto Matteo

Serafino Suriano

Antonio Troccoli

Nicola Pecchioni

Clementina Manera

Lorenzo Di Cesare Mannelli

Carla Ghelardini

Affiliations

Soon will be listed here.

Abstract

are natural sources of bioactive compounds able to promote gut health. Belonging to this plant family, is an ancient oil crop rich in glucosinolates, polyunsaturated fatty acids, and antioxidants that is attracting renewed attention for its nutraceutical potential. This work aimed at investigating the therapeutic effects of a defatted seed meal (DSM) of on the colon damage and the persistent visceral hypersensitivity associated with colitis in rats. Inflammation was induced by the intrarectal injection of 2,4-dinitrobenzenesulfonic acid (DNBS). The acute administration of DSM (0.1-1 g kg) showed a dose-dependent pain-relieving effect in DNBS-treated rats. The efficacy of the meal was slightly enhanced after bioactivation with myrosinase, which increased isothiocyanate availability, and drastically decreased by pre-treating the animals with the selective peroxisome proliferator-activated receptor alpha (PPAR α) receptor antagonist GW6471. Repeated treatments with DSM (1 g kg) meal counteracted the development, as well as the persistence, of visceral hyperalgesia in DNBS-treated animals by reducing the intestinal inflammatory damage and preventing enteric neuron damage. In conclusion, meal might be employed as a nutraceutical tool to manage persistent abdominal pain in patients and to promote gut healing.

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