The Biological and Clinical Relevance of G Protein-Coupled Receptors to the Outcomes of Hematopoietic Stem Cell Transplantation: A Systematized Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Aug 14

PMID 31404983

Citations 2

Authors

Hadrien Golay

Simona Jurkovic Mlakar

Vid Mlakar

Tiago Nava

Marc Ansari

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for several malignant and non-malignant diseases at the cost of serious treatment-related toxicities (TRTs). Recent research on extending the benefits of HSCT to more patients and indications has focused on limiting TRTs and improving immunological effects following proper mobilization and engraftment. Increasing numbers of studies report associations between HSCT outcomes and the expression or the manipulation of G protein-coupled receptors (GPCRs). This large family of cell surface receptors is involved in various human diseases. With ever-better knowledge of their crystal structures and signaling dynamics, GPCRs are already the targets for one third of the current therapeutic arsenal. The present paper assesses the current status of animal and human research on GPCRs in the context of selected HSCT outcomes via a systematized survey and analysis of the literature.

Citing Articles

A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs).

Adamiak M, Cymer M, Anusz K, Tracz M, Ratajczak M Stem Cell Rev Rep. 2020; 16(4):693-701.

PMID: 32406006 PMC: 7392939. DOI: 10.1007/s12015-020-09983-8.

Special Issue: G Protein-Coupled Adenosine Receptors: Molecular Aspects and Beyond.

Ciruela F Int J Mol Sci. 2020; 21(6).

PMID: 32183407 PMC: 7139776. DOI: 10.3390/ijms21061997.

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