The Role of H3K79 Methylation in Transcription and the DNA Damage Response

Overview

Journal Mutat Res Rev Mutat Res

Specialty Genetics

Date 2019 Aug 10

PMID 31395348

Citations 10

Authors

Mats Ljungman

Luke Parks

Radhika Hulbatte

Karan Bedi

Affiliations

Soon will be listed here.

Abstract

Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response. This review summarizes the current understanding of the role of H3K79 methylation in transcription, how it affects genome stability and opportunities to develop impactful therapeutic interventions for cancer.

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