Emerging Roles of LncRNA in Cancer and Therapeutic Opportunities

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2019 Aug 9

PMID 31392074

Citations 290

Authors

Ming-Chun Jiang

Jiao-Jiao Ni

Wen-Yu Cui

Bo-Ya Wang

Wei Zhuo

Affiliations

Soon will be listed here.

Abstract

Cancer is difficult to cure due to frequent metastasis, and developing effective therapeutic approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have diverse roles in regulating gene expression at both the transcriptional and translational levels and have been reported to be involved in tumorigenesis and tumor metastasis. In this article, we review the emerging roles of lncRNAs in cancer, especially in cancer immunity, cancer metabolism and cancer metastasis. We also discuss the use of novel technologies, such as antisense oligonucleotides, CRISPR-Cas9 and nanomedicines, to target lncRNAs and thus control cancers.

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