Comprehensive Insights and In Silico Analysis into the Emerging Role of LincRNAs in Lung Diseases Pathogenesis; a Step Toward NcRNA Precision

Overview

Journal Funct Integr Genomics

Publisher Springer

Date 2025 Feb 6

PMID 39912974

Authors

Nadia M Hamdy

Mohamed Bakr Zaki

Nourhan M Abdelmaksoud

Shereen Saeid Elshaer

Mai A Abd-Elmawla

Nehal I Rizk

Doaa Fathi

Ahmed S Doghish

Ahmed I Abulsoud

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) have emerged as essential regulators of gene expression, significantly influencing various biological processes. Approximately half of all lncRNAs are classified as long intergenic non-coding RNAs (lincRNAs), which are situated among coding genes. Recent studies have documented the role of lincRNAs in the pathogenesis of lung diseases, including lung cancer, pulmonary fibrosis, and pulmonary arterial hypertension. These lincRNAs can modulate gene expression through various mechanisms, including epigenetic modifications, transcriptional regulation, and post-transcriptional regulation. By functioning as competing endogenous RNAs (ceRNAs), lincRNAs can affect the activity of microRNAs (miRNAs) and their corresponding target genes. This review delves into the intricate mechanisms by which lincRNAs contribute to the development and progression of various lung diseases. Furthermore, it discusses the potential of lincRNAs as therapeutic targets.

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