Sequence Assignment for Low-resolution Modelling of Protein Crystal Structures

Overview

Journal Acta Crystallogr D Struct Biol

Specialty Biochemistry

Date 2019 Aug 3

PMID 31373574

Citations 14

Authors

Grzegorz Chojnowski

Joana Pereira

Victor S Lamzin

Affiliations

Soon will be listed here.

Abstract

The performance of automated model building in crystal structure determination usually decreases with the resolution of the experimental data, and may result in fragmented models and incorrect side-chain assignment. Presented here are new methods for machine-learning-based docking of main-chain fragments to the sequence and for their sequence-independent connection using a dedicated library of protein fragments. The combined use of these new methods noticeably increases sequence coverage and reduces fragmentation of the protein models automatically built with ARP/wARP.

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