Differential Effect of Amitriptyline and Bupropion on Primary and Secondary Depression: a Pilot Study

Overview

Journal J Clin Psychiatry

Specialty Psychiatry

Date 1988 Aug 1

PMID 3137218

Citations 32

Authors

S C Othmer

E OTHMER

S H Preskorn

D Mac

Affiliations

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Abstract

In a prospective, controlled, double-blind study, 37 patients with major depressive disorder were subclassified into primary depression (N = 25) and secondary (N = 12) depression and treated with either amitriptyline (primary depressives N = 13, secondary depressives N = 6) or bupropion (primary depressives N = 12, secondary depressives N = 6). A differential response to the novel antidepressant bupropion was observed between the two diagnostic subgroups, but no differential response to amitriptyline was observed; patients with primary depression and secondary depression responded equally well to amitriptyline but not to bupropion. Our results provide pharmacological evidence supporting the usefulness of this subclassification of depression.

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