Multiple Ancestral Haplotypes Harboring Regulatory Mutations Cumulatively Contribute to a QTL Affecting Chicken Growth Traits

Overview

Journal Commun Biol

Specialty Biology

Date 2020 Aug 30

PMID 32859973

Citations 19

Authors

Yuzhe Wang

Xuemin Cao

Chenglong Luo

Zheya Sheng

Chunyuan Zhang

Cheng Bian

Chungang Feng

Jinxiu Li

Fei Gao

Yiqiang Zhao

Ziqin Jiang

Hao Qu

Dingming Shu

Orjan Carlborg

Xiaoxiang Hu

Ning Li

Affiliations

Soon will be listed here.

Abstract

In depth studies of quantitative trait loci (QTL) can provide insights to the genetic architectures of complex traits. A major effect QTL at the distal end of chicken chromosome 1 has been associated with growth traits in multiple populations. This locus was fine-mapped in a fifteen-generation chicken advanced intercross population including 1119 birds and explored in further detail using 222 sequenced genomes from 10 high/low body weight chicken stocks. We detected this QTL that, in total, contributed 14.4% of the genetic variance for growth. Further, nine mosaic precise intervals (Kb level) which contain ancestral regulatory variants were fine-mapped and we chose one of them to demonstrate the key regulatory role in the duodenum. This is the first study to break down the detail genetic architectures for the well-known QTL in chicken and provides a good example of the fine-mapping of various of quantitative traits in any species.

Citing Articles

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