Extranodal Rosai-Dorfman of the Pancreas Presents with Bilateral Granulomatous Anterior Uveitis

Overview

Journal Ocul Oncol Pathol

Date 2019 Aug 2

PMID 31367582

Citations 2

Authors

Asha Brown

Sara V Branson

Ghazala A Datoo OKeefe

Affiliations

Soon will be listed here.

Abstract

Background/aims: To report a case of a 65-year-old female who presented with bilateral anterior granulomatous uveitis, which led to the diagnosis of Rosai-Dorfman Disease (RDD) and the discovery of an associated pancreatic mass.

Methods: This is a retrospective case report of a single patient.

Results: A 65-year-old African American Female received a full workup for bilateral anterior granulomatous uveitis and was found to have a pancreatic mass on imaging. Biopsy of this mass was diagnostic for RDD, a rare proliferative histiocytic disorder, which classically presents with painless cervical lymphadenopathy, leukocytosis, and hypergammaglobulinemia.

Conclusion: Although rare, ocular involvement, including eyelid and orbital masses, and anterior uveitis, can herald the development of other systemic manifestations or RDD and can aid in the diagnosis of this systemic disease.

Citing Articles

Rosai-Dorfman disease as chronic bilateral granulomatous anterior uveitis: A case report.

Ngathaweesuk Y, Jumroendararasame C SAGE Open Med Case Rep. 2024; 12:2050313X241239528.

PMID: 38505579 PMC: 10949540. DOI: 10.1177/2050313X241239528.

Pancreatic involvement in Erdheim-Chester disease: a case report and review of the literature.

Dai J, He T, Duan M, Li Y, Cao X BMC Gastroenterol. 2022; 22(1):302.

PMID: 35729495 PMC: 9210604. DOI: 10.1186/s12876-022-02378-8.

References

Silvestre J, Aliaga A . Cutaneous sinus histiocytosis and chronic uveitis. Pediatr Dermatol. 2000; 17(5):377-80. DOI: 10.1046/j.1525-1470.2000.017005377.x. View

Rumelt S, Cohen I, Rehany U . Marginal corneal infiltrates: a possible new manifestation of sinus histiocytosis with massive lymphadenopathy. Cornea. 2000; 19(6):857-8. DOI: 10.1097/00003226-200011000-00020. View

Salim A, Williamson M, Barker F, Hughes J . Steroid responsive cutaneous Rosai-Dorfman disease associated with uveitis and hypothyroidism. Clin Exp Dermatol. 2002; 27(4):277-9. DOI: 10.1046/j.1365-2230.2002.01020.x. View

Tan H, Kao L . Rosai-Dorfman disease manifesting as relapsing uveitis and subconjunctival masses. Chang Gung Med J. 2002; 25(9):621-5. View

Sakai Y, Atsumi T, Itoh T, Koike T . Uveitis, pancarditis, haemophagocytosis, and abdominal masses. Lancet. 2003; 361(9360):834. DOI: 10.1016/S0140-6736(03)12711-0. View

Meyer C, Sel S, Horle S, Burg J, Kroll P . Rosai-Dorfman disease with bilateral serous retinal detachment. Arch Ophthalmol. 2003; 121(5):733-5. DOI: 10.1001/archopht.121.5.733. View

Gaviria J, A Johnson D, Kinney M, Proffer L, Losi-Sasaki J, Kraus E . Bilateral anterior granulomatous uveitis associated with cutaneous Rosai-Dorfman disease. Graefes Arch Clin Exp Ophthalmol. 2005; 243(3):281-4. DOI: 10.1007/s00417-004-0993-9. View

Nakashima M, Matsui Y, Kobayashi S . Relapsing uveitis in association with presumed sinus histiocytosis. Jpn J Ophthalmol. 2006; 50(5):484-486. DOI: 10.1007/s10384-006-0356-7. View

MacLaren R, Hundal K, Trittibach P, Bloom P . Uveitic glaucoma and Rosai-Dorfman disease (sinus histiocytosis). Ocul Immunol Inflamm. 2006; 14(5):305-7. DOI: 10.1080/09273940600878829. View

10.

Huang Y, Tan H, Jung S, Chuang W, Chuang C, Hsu P . Spinal epidural Rosai-Dorfman disease preceding by relapsing uveitis: a case report with literature review. Spinal Cord. 2007; 45(9):641-4. DOI: 10.1038/sj.sc.3102006. View

11.

Sarwal R, Tu E, Mendelblatt F, Sugar J, Gross S, Pulido J . Atypical ocular presentations of Rosai-Dorfman disease. Ocul Immunol Inflamm. 2008; 16(1):9-15. DOI: 10.1080/09273940801923911. View

12.

Payne J, Srivastava S, Wells J, Grossniklaus H . Rosai-Dorfman disease simulating nodular scleritis and panuveitis. Arch Ophthalmol. 2011; 129(4):518-20. PMC: 3410937. DOI: 10.1001/archophthalmol.2011.56. View

13.

Shah A, Bielory L, Mirani N, Tu Y, Chu D . Epibulbar rosai-dorfman disease: novel manifestation and treatment. Arch Ophthalmol. 2012; 130(9):1218-20. DOI: 10.1001/archophthalmol.2012.12. View

14.

Monroe A, Burkholder B, Butler N, Duffield A . Sclerouveitis associated with Rosai-Dorfman disease in an HIV-infected patient. Ocul Immunol Inflamm. 2014; 22(3):236-8. DOI: 10.3109/09273948.2013.767914. View

15.

Cai Y, Shi Z, Bai Y . Review of Rosai-Dorfman Disease: New Insights into the Pathogenesis of This Rare Disorder. Acta Haematol. 2017; 138(1):14-23. DOI: 10.1159/000475588. View

16.

Foucar E, Rosai J, DORFMAN R . The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy. Am J Ophthalmol. 1979; 87(3):354-67. DOI: 10.1016/0002-9394(79)90077-1. View

17.

Rosai J, DORFMAN R . Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer. 1972; 30(5):1174-88. DOI: 10.1002/1097-0142(197211)30:5<1174::aid-cncr2820300507>3.0.co;2-s. View