The Non-coding RNA Landscape of Human Hematopoiesis and Leukemia

Overview

Journal Nat Commun

Specialty Biology

Date 2017 Aug 11

PMID 28794406

Citations 87

Authors

Adrian Schwarzer

Stephan Emmrich

Franziska Schmidt

Dominik Beck

Michelle Ng

Christina Reimer

Felix Ferdinand Adams

Sarah Grasedieck

Damian Witte

Sebastian Kabler

Jason W H Wong

Anushi Shah

Yizhou Huang

Razan Jammal

Aliaksandra Maroz

Mojca Jongen-Lavrencic

Axel Schambach

Florian Kuchenbauer

John E Pimanda

Dirk Reinhardt

Dirk Heckl

Jan-Henning Klusmann

Affiliations

Soon will be listed here.

Abstract

Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the human hematopoietic system. Based on highly specific non-coding RNA expression portraits per blood cell population, we identify unique fingerprint non-coding RNAs-such as LINC00173 in granulocytes-and assign these to critical regulatory circuits involved in blood homeostasis. Following the incorporation of acute myeloid leukemia samples into the landscape, we further uncover prognostically relevant non-coding RNA stem cell signatures shared between acute myeloid leukemia blasts and healthy hematopoietic stem cells. Our findings highlight the importance of the non-coding transcriptome in the formation and maintenance of the human blood hierarchy.While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in the formation and maintenance of the human blood hierarchy.

Citing Articles

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