CTC Analysis: an Update on Technological Progress

Overview

Journal Transl Res

Publisher Elsevier

Specialty Pathology

Date 2019 Jul 27

PMID 31348892

Citations 18

Authors

Izhar S Batth

Abhisek Mitra

Sierra Rood

Scott Kopetz

David Menter

Shulin Li

Affiliations

Soon will be listed here.

Abstract

There is a growing need for a more accurate, real-time assessment of tumor status and the probability of metastasis, relapse, or response to treatment. Conventional means of assessment include imaging and tissue biopsies that can be highly invasive, may not provide complete information of the disease's heterogeneity, and not ideal for repeat analysis. Therefore, a less-invasive means of acquiring similar information at greater time points is necessary. Liquid biopsies are samples of a patients' peripheral blood and hold potential of addressing these criteria. Ongoing research has revealed that a tumor can release circulating cells, genetic materials (DNA or RNA), and exosomes into circulation. These potential biomarkers can be captured in a liquid biopsy and analyzed to determine disease status. To achieve these goals, numerous technologies have been developed. In this review, we discuss both prominent and newly developed technologies for circulating tumor cell capture and analysis and their clinical impact.

Citing Articles

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