MR-guided Radiotherapy in Rectal Cancer: First Clinical Experience of an Innovative Technology

Overview

Journal Clin Transl Radiat Oncol

Specialty Oncology

Date 2019 Jul 26

PMID 31341981

Citations 35

Authors

Giuditta Chiloiro

Luca Boldrini

Elisa Meldolesi

Alessia Re

Francesco Cellini

Davide Cusumano

Barbara Corvari

Giovanna Mantini

Mario Balducci

Vincenzo Valentini

Maria Antonietta Gambacorta

Affiliations

Soon will be listed here.

Abstract

•This study represents one of the first reports of online MRgRT.•Integrated Low-field MR provides better anatomical visualization than CBCT or MVCT.•Better visualization of the target can help to reduce the margins from CTV to PTV.•MRgRT appears a feasible option in rectal cancer treatment offering potential benefits.•MRgRT represents a promising technology for rectal cancer management.

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References

Capirci C, Valentini V, Cionini L, De Paoli A, Rodel C, Glynne-Jones R . Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients. Int J Radiat Oncol Biol Phys. 2008; 72(1):99-107. DOI: 10.1016/j.ijrobp.2007.12.019. View

Van Wickle J, Paulson E, Landry J, Erickson B, Hall W . Adaptive radiation dose escalation in rectal adenocarcinoma: a review. J Gastrointest Oncol. 2017; 8(5):902-914. PMC: 5674246. DOI: 10.21037/jgo.2017.07.06. View

Bosset J, Magnin V, Maingon P, Mantion G, Pelissier E, Mercier M . Preoperative radiochemotherapy in rectal cancer: long-term results of a phase II trial. Int J Radiat Oncol Biol Phys. 2000; 46(2):323-7. DOI: 10.1016/s0360-3016(99)00411-3. View

Arbea L, Ramos L, Martinez-Monge R, Moreno M, Aristu J . Intensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications. Radiat Oncol. 2010; 5:17. PMC: 2845593. DOI: 10.1186/1748-717X-5-17. View

Hernando-Requejo O, Lopez M, Cubillo A, Rodriguez A, Ciervide R, Valero J . Complete pathological responses in locally advanced rectal cancer after preoperative IMRT and integrated-boost chemoradiation. Strahlenther Onkol. 2014; 190(6):515-20. DOI: 10.1007/s00066-014-0650-0. View

Uh J, Merchant T, Li Y, Li X, Hua C . MRI-based treatment planning with pseudo CT generated through atlas registration. Med Phys. 2014; 41(5):051711. PMC: 5148041. DOI: 10.1118/1.4873315. View

Burbach J, den Harder A, Intven M, van Vulpen M, Marieke Verkooijen H, Reerink O . Impact of radiotherapy boost on pathological complete response in patients with locally advanced rectal cancer: a systematic review and meta-analysis. Radiother Oncol. 2014; 113(1):1-9. DOI: 10.1016/j.radonc.2014.08.035. View

Bosset J, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L . Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006; 355(11):1114-23. DOI: 10.1056/NEJMoa060829. View

Valentini V, van Stiphout R, Lammering G, Gambacorta M, Barba M, Bebenek M . Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials. J Clin Oncol. 2011; 29(23):3163-72. DOI: 10.1200/JCO.2010.33.1595. View

10.

Chan A, Wong A, Langevin J, Jenken D, Heine J, Buie D . Preoperative chemotherapy and pelvic radiation for tethered or fixed rectal cancer: a phase II dose escalation study. Int J Radiat Oncol Biol Phys. 2000; 48(3):843-56. DOI: 10.1016/s0360-3016(00)00692-1. View

11.

Boldrini L, Cusumano D, Chiloiro G, Casa C, Masciocchi C, Lenkowicz J . Delta radiomics for rectal cancer response prediction with hybrid 0.35 T magnetic resonance-guided radiotherapy (MRgRT): a hypothesis-generating study for an innovative personalized medicine approach. Radiol Med. 2018; 124(2):145-153. PMC: 6373341. DOI: 10.1007/s11547-018-0951-y. View

12.

Boldrini L, Placidi E, Dinapoli N, Azario L, Cellini F, Massaccesi M . Hybrid Tri-Co-60 MRI radiotherapy for locally advanced rectal cancer: An evaluation. Tech Innov Patient Support Radiat Oncol. 2020; 6:5-10. PMC: 7033778. DOI: 10.1016/j.tipsro.2018.02.002. View

13.

Arbea L, Martinez-Monge R, Diaz-Gonzalez J, Moreno M, Rodriguez J, Hernandez J . Four-week neoadjuvant intensity-modulated radiation therapy with concurrent capecitabine and oxaliplatin in locally advanced rectal cancer patients: a validation phase II trial. Int J Radiat Oncol Biol Phys. 2011; 83(2):587-93. DOI: 10.1016/j.ijrobp.2011.06.2008. View

14.

Valentini V, Gambacorta M, Barbaro B, Chiloiro G, Coco C, Das P . International consensus guidelines on Clinical Target Volume delineation in rectal cancer. Radiother Oncol. 2016; 120(2):195-201. DOI: 10.1016/j.radonc.2016.07.017. View

15.

Verellen D, de Ridder M, Tournel K, Duchateau M, Reynders T, Gevaert T . An overview of volumetric imaging technologies and their quality assurance for IGRT. Acta Oncol. 2008; 47(7):1271-8. DOI: 10.1080/02841860802244182. View

16.

Zorcolo L, Rosman A, Restivo A, Pisano M, Nigri G, Fancellu A . Complete pathologic response after combined modality treatment for rectal cancer and long-term survival: a meta-analysis. Ann Surg Oncol. 2012; 19(9):2822-32. DOI: 10.1245/s10434-011-2209-y. View

17.

Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R . Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004; 351(17):1731-40. DOI: 10.1056/NEJMoa040694. View

18.

Noel C, Parikh P, Spencer C, Green O, Hu Y, Mutic S . Comparison of onboard low-field magnetic resonance imaging versus onboard computed tomography for anatomy visualization in radiotherapy. Acta Oncol. 2015; 54(9):1474-82. DOI: 10.3109/0284186X.2015.1062541. View

19.

Valentini V, Glimelius B, Haustermans K, Marijnen C, Rodel C, Gambacorta M . EURECCA consensus conference highlights about rectal cancer clinical management: the radiation oncologist's expert review. Radiother Oncol. 2013; 110(1):195-8. DOI: 10.1016/j.radonc.2013.10.024. View

20.

Mohiuddin M, Regine W, John W, Hagihara P, McGrath P, Kenady D . Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys. 2000; 46(4):883-8. DOI: 10.1016/s0360-3016(99)00486-1. View