Effect of the Probiotic IS-10506 on BDNF and 5HT Stimulation: Role of Intestinal Microbiota on the Gut-brain Axis

Overview

Journal Iran J Microbiol

Publisher Tehran University of Medical Sciences

Specialty Infectious Diseases

Date 2019 Jul 26

PMID 31341569

Citations 35

Authors

Reza Ranuh

Alpha Fardah Athiyyah

Andy Darma

Vitria Prasetyo Risky

Wibi Riawan

Ingrid S Surono

Subijanto Marto Sudarmo

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Microbial communities residing in the gut play a major role in the communication between the gut and the brain through neural, immune, and hormonal routes. Changes in abundance of beneficial intestinal bacteria can affect health of individuals. Conversely, drugs, disease, diet and other factors can alter the gut microbiome. However, there is limited information on the effect of exogenous factors on gut microbiota. In this study, we investigated whether a beneficial bacterium, the probiotic IS-10506, can stimulate the gut-brain axis using Wistar rats.

Materials And Methods: The animals were divided into two groups: one received IS strain 10506 supplementation, while the control group received no treatment. Activation of the gut-brain axis was evaluated by immunohistochemical analysis of intestinal and brain serotonin (5-HT) and brain neurotrophin (NT), serotonin transporter (5-HTT), and brain-derived neurotrophic factor (BDNF) levels.

Results: The results showed that BDNF (< 0.000), NT (< 0.000007), and 5-HTT (< 0.000007) expression was upregulated in the brain along with intestinal 5-HT (< 0.000) level in rats treated with strain IS-10506 relative to the control group.

Conclusion: The probiotic IS-10506 stimulates the gut-brain axis and can potentially promote brain development and function.

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