Development of Dopaminergic Genetic Associations with Visuospatial, Verbal and Social Working Memory

Overview

Journal Dev Sci

Specialty Psychology

Date 2019 Jul 24

PMID 31336006

Citations 5

Authors

Iroise Dumontheil

Emma J Kilford

Sarah-Jayne Blakemore

Affiliations

Soon will be listed here.

Abstract

Dopamine transmission in the prefrontal cortex (PFC) supports working memory (WM), the temporary holding, processing and manipulation of information in one's mind. The gene coding the catechol-O-methyltransferase (COMT) enzyme, which degrades dopamine, in particular in the PFC, has a common single nucleotide polymorphism leading to two versions of the COMT enzyme which vary in their enzymatic activity. The methionine (Met) allele has been associated with higher WM performance and lower activation of the PFC in executive function tasks than the valine (Val) allele. In a previous study, COMT genotype was associated with performance on verbal and visuospatial WM tasks in adults, as well as with performance on a novel social WM paradigm that requires participants to maintain and manipulate information about the traits of their friends or family over a delay. Here, data collected in children and adolescents (N = 202) were compared to data from the adult sample (N = 131) to investigate possible age differences in genetic associations. Our results replicate and extend previous work showing that the pattern of superior WM performance observed in Met/Met adults emerges during development. These findings are consistent with a decrease in prefrontal dopamine levels during adolescence. Developmentally moderated genetic effects were observed for both visuospatial and social WM, even when controlling for non-social WM performance, suggesting that the maintenance and manipulation of social information may also recruit the dopamine neurotransmitter system. These findings show that development should be considered when trying to understand the impact of genetic polymorphisms on cognitive function.

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References

Meyer M, Spunt R, Berkman E, Taylor S, Lieberman M . Evidence for social working memory from a parametric functional MRI study. Proc Natl Acad Sci U S A. 2012; 109(6):1883-8. PMC: 3277536. DOI: 10.1073/pnas.1121077109. View

Mehta M, Owen A, Sahakian B, Mavaddat N, Pickard J, Robbins T . Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci. 2000; 20(6):RC65. PMC: 6772505. View

Rosenberg D, Lewis D . Changes in the dopaminergic innervation of monkey prefrontal cortex during late postnatal development: a tyrosine hydroxylase immunohistochemical study. Biol Psychiatry. 1994; 36(4):272-7. DOI: 10.1016/0006-3223(94)90610-6. View

Witte A, Floel A . Effects of COMT polymorphisms on brain function and behavior in health and disease. Brain Res Bull. 2011; 88(5):418-28. DOI: 10.1016/j.brainresbull.2011.11.012. View

Nickl-Jockschat T, Janouschek H, Eickhoff S, Eickhoff C . Lack of meta-analytic evidence for an impact of COMT Val158Met genotype on brain activation during working memory tasks. Biol Psychiatry. 2015; 78(11):e43-6. DOI: 10.1016/j.biopsych.2015.02.030. View

Wahlstrom D, White T, Luciana M . Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neurosci Biobehav Rev. 2009; 34(5):631-48. PMC: 2845533. DOI: 10.1016/j.neubiorev.2009.12.007. View

Magis-Weinberg L, Blakemore S, Dumontheil I . Social and Nonsocial Relational Reasoning in Adolescence and Adulthood. J Cogn Neurosci. 2017; 29(10):1739-1754. PMC: 5889095. DOI: 10.1162/jocn_a_01153. View

Dickinson D, Elvevag B . Genes, cognition and brain through a COMT lens. Neuroscience. 2009; 164(1):72-87. PMC: 2760675. DOI: 10.1016/j.neuroscience.2009.05.014. View

Crone E, Dahl R . Understanding adolescence as a period of social-affective engagement and goal flexibility. Nat Rev Neurosci. 2012; 13(9):636-50. DOI: 10.1038/nrn3313. View

10.

Seeman P, Bzowej N, Guan H, Bergeron C, Becker L, Reynolds G . Human brain dopamine receptors in children and aging adults. Synapse. 1987; 1(5):399-404. DOI: 10.1002/syn.890010503. View

11.

Harrison P, Tunbridge E . Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology. 2007; 33(13):3037-45. DOI: 10.1038/sj.npp.1301543. View

12.

Mattay V, Goldberg T, Fera F, Hariri A, Tessitore A, Egan M . Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A. 2003; 100(10):6186-91. PMC: 156347. DOI: 10.1073/pnas.0931309100. View

13.

Skuse D, Gallagher L . Genetic influences on social cognition. Pediatr Res. 2011; 69(5 Pt 2):85R-91R. DOI: 10.1203/PDR.0b013e318212f562. View

14.

Mannisto P, Kaakkola S . Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev. 1999; 51(4):593-628. View

15.

Conway A, Kane M, Engle R . Working memory capacity and its relation to general intelligence. Trends Cogn Sci. 2003; 7(12):547-52. DOI: 10.1016/j.tics.2003.10.005. View

16.

Dumontheil I, Roggeman C, Ziermans T, Peyrard-Janvid M, Matsson H, Kere J . Influence of the COMT genotype on working memory and brain activity changes during development. Biol Psychiatry. 2011; 70(3):222-9. DOI: 10.1016/j.biopsych.2011.02.027. View

17.

Jucaite A, Forssberg H, Karlsson P, Halldin C, Farde L . Age-related reduction in dopamine D1 receptors in the human brain: from late childhood to adulthood, a positron emission tomography study. Neuroscience. 2010; 167(1):104-10. DOI: 10.1016/j.neuroscience.2010.01.034. View

18.

Wahlstrom D, White T, Hooper C, Vrshek-Schallhorn S, Oetting W, Brott M . Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents. Biol Psychiatry. 2006; 61(5):626-32. DOI: 10.1016/j.biopsych.2006.05.045. View

19.

Ziermans T, Dumontheil I, Roggeman C, Peyrard-Janvid M, Matsson H, Kere J . Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development. Transl Psychiatry. 2012; 2:e85. PMC: 3309555. DOI: 10.1038/tp.2012.7. View

20.

Dumontheil I, Kuster O, Apperly I, Blakemore S . Taking perspective into account in a communicative task. Neuroimage. 2010; 52(4):1574-83. DOI: 10.1016/j.neuroimage.2010.05.056. View