The Zn(II)-1,4,7-Trimethyl-1,4,7-Triazacyclononane Complex: A Monometallic Catalyst Active in Two Protonation States

Overview

Journal Front Chem

Specialty Chemistry

Date 2019 Jul 24

PMID 31334218

Citations 3

Authors

Marta Diez-Castellnou

Giovanni Salassa

Fabrizio Mancin

Paolo Scrimin

Affiliations

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Abstract

In this paper, the unusual reactivity of the complex Zn(II)-1,4,7-trimethyl-1, 4,7-triazacyclononane () in the transesterification of the RNA-model substrate, (), is reported. The dependence of the reactivity (k) with pH does not follow the characteristic bell-shape profile typical of complexes with penta-coordinated metal centers. By the contrary, two reactive species, featuring different deprotonation states, are present, with the tri-aqua complex being more reactive than the mono-hydroxy-diaqua one. Apparently, such a difference arises from the total complex charge which plays an important role in the stability of the transition state/s of the reactions. Relevant insight on the reaction mechanism were hence obtained.

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