Insights on Nuclease Mechanism: the Role of Proximal Ammonium Group on Phosphate Esters Cleavage

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2009 Jul 25

PMID 19627082

Citations 5

Authors

Renato Bonomi

Giacomo Saielli

Umberto Tonellato

Paolo Scrimin

Fabrizio Mancin

Affiliations

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Abstract

The role of remotely located ammonium groups in the active site of many phosphate-cleaving enzymes is investigated by using model systems thus providing mechanistic hints to a still unsolved problem.

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