Effects of 'Superhongmi' Rice Bran Extracts on Biochemical Markers of Glycolysis and Bone Metabolism in Ovariectomized Rats

Overview

Journal Prev Nutr Food Sci

Date 2019 Jul 23

PMID 31328118

Authors

Soo Im Chung

Young In Kwon

Mi Young Kang

Affiliations

Soon will be listed here.

Abstract

Middle aged women naturally enter menopause, which increases the risk of several metabolic diseases. The objective of this research was to investigate the regulatory effects of bioactive natural product "Superhongmi" rice bran on hyperglycemia, oxidative stress, and bone metabolism. The ovariectomized Sprague-Dawley rats were randomly divided into three dietary groups (n=10): ovariectomized (OVX)-AIN93M diet (OVX-AIN93M) and OVX-AIN93M diet supplemented with either low dose Superhongmi extract (1 g/kg, OVX-LSH) or high dose Superhongmi extract (5 g/kg, OVXHSH). Body weight, activities of glucose regulatory, antioxidant enzymes, and bone metabolism biochemical markers of rats were measured. After eight weeks of feeding, the OVX-AIN93M group showed a significant increase in body weight gain relative to the sham-operated group. Superhongmi extract diet supplementation (OVX-HSH group) significantly suppressed hyperglycemia, oxidative stress, and bone resorption. These findings indicated that OVX-HSH has a potential therapeutic effect on menopause women.

References

Halliwell B . Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?. Lancet. 1994; 344(8924):721-4. DOI: 10.1016/s0140-6736(94)92211-x. View

Matschinsky F . Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes. 1990; 39(6):647-52. DOI: 10.2337/diab.39.6.647. View

Paglia D, Valentine W . Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1):158-69. View

Aruoma O . Free radicals, oxidative stress, and antioxidants in human health and disease. J Am Oil Chem Soc. 2020; 75(2):199-212. PMC: 7101596. DOI: 10.1007/s11746-998-0032-9. View

MIZE C, Langdon R . Hepatic glutathione reductase. I. Purification and general kinetic properties. J Biol Chem. 1962; 237:1589-95. View

Mackness M, Arrol S, Durrington P . Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 1991; 286(1-2):152-4. DOI: 10.1016/0014-5793(91)80962-3. View

Goufo P, Trindade H . Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sci Nutr. 2014; 2(2):75-104. PMC: 3959956. DOI: 10.1002/fsn3.86. View

Qureshi A, Sami S, Khan F . Effects of stabilized rice bran, its soluble and fiber fractions on blood glucose levels and serum lipid parameters in humans with diabetes mellitus Types I and II. J Nutr Biochem. 2002; 13(3):175-187. DOI: 10.1016/s0955-2863(01)00211-x. View

Satue M, Arriero M, Monjo M, Ramis J . Quercitrin and taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells. Biochem Pharmacol. 2013; 86(10):1476-86. DOI: 10.1016/j.bcp.2013.09.009. View

10.

Posuwan J, Prangthip P, Leardkamolkarn V, Yamborisut U, Surasiang R, Charoensiri R . Long-term supplementation of high pigmented rice bran oil (Oryza sativa L.) on amelioration of oxidative stress and histological changes in streptozotocin-induced diabetic rats fed a high fat diet; Riceberry bran oil. Food Chem. 2012; 138(1):501-8. DOI: 10.1016/j.foodchem.2012.09.144. View

11.

Newton K, Reed S, Grothaus L, Ehrlich K, Guiltinan J, Ludman E . The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas. 2005; 52(2):134-46. DOI: 10.1016/j.maturitas.2005.01.007. View

12.

Knapen M, Nieuwenhuijzen Kruseman A, Wouters R, Vermeer C . Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int. 1998; 63(5):375-9. DOI: 10.1007/s002239900543. View

13.

Zhao Y, Huang W, Wang J, Chen Y, Huang W, Zhu Y . Taxifolin attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Am J Transl Res. 2018; 10(4):1205-1210. PMC: 5934579. View

14.

Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin H . Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005; 105(5 Pt 1):1074-83. DOI: 10.1097/01.AOG.0000158865.98070.89. View

15.

Zhang F, Wang Q, Pu Y, Chen T, Qin X, Gao J . Identification of Genes Involved in Flavonoid Biosynthesis in Sophora japonica Through Transcriptome Sequencing. Chem Biodivers. 2017; 14(12). DOI: 10.1002/cbdv.201700369. View

16.

Sun X, Chen R, Yang Z, Sun G, Wang M, Ma X . Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013; 63:221-32. DOI: 10.1016/j.fct.2013.11.013. View

17.

Chung S, Ryu S, Kang M . Germinated Pigmented Rice (Oryza Sativa L. cv. Superhongmi) Improves Glucose and Bone Metabolisms in Ovariectomized Rats. Nutrients. 2016; 8(10). PMC: 5084044. DOI: 10.3390/nu8100658. View

18.

Kronenberg F, Fugh-Berman A . Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002; 137(10):805-13. DOI: 10.7326/0003-4819-137-10-200211190-00009. View

19.

Davidson A, ARION W . Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch Biochem Biophys. 1987; 253(1):156-67. DOI: 10.1016/0003-9861(87)90648-5. View

20.

Alegre M, Ciudad C, Fillat C, Guinovart J . Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal Biochem. 1988; 173(1):185-9. DOI: 10.1016/0003-2697(88)90176-5. View