Viral Hijacking of Cellular Metabolism

Overview

Journal BMC Biol

Publisher Biomed Central

Specialty Biology

Date 2019 Jul 20

PMID 31319842

Citations 237

Authors

Shivani K Thaker

James Chng

Heather R Christofk

Affiliations

Soon will be listed here.

Abstract

This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to identify critical metabolic nodes for cancer anabolism. We also discuss the need for more mechanistic studies identifying viral proteins responsible for metabolic hijacking and for in vivo studies of viral-induced metabolic rewiring. Improved technologies for detailed metabolic measurements and genetic manipulation will lead to important discoveries over the next decade.

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