Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase-1

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2010 Oct 12

PMID 20935628

Citations 186

Authors

Eva Herker

Charles Harris

Celine Hernandez

Arnaud Carpentier

Katrin Kaehlcke

Arielle R Rosenberg

Robert V Farese Jr

Melanie Ott

Affiliations

Soon will be listed here.

Abstract

Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.

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