Mediation of Antiinflammatory Effects of Rg3-enriched Red Ginseng Extract from Korean Red Ginseng Via Retinoid X Receptor α-peroxisome-proliferating Receptor γ Nuclear Receptors

Overview

Journal J Ginseng Res

Date 2019 Jul 17

PMID 31308816

Citations 9

Authors

Evelyn Saba

Muhammad Irfan

Dahye Jeong

Kashif Ameer

Yuan Yee Lee

Chae-Kyu Park

Seung-Bok Hong

Man Hee Rhee

Affiliations

Soon will be listed here.

Abstract

Background: Ginseng has a wide range of beneficial effects on health, such as the mitigation of minor and major inflammatory diseases, cancer, and cardiovascular diseases. There are abundant data regarding the health-enhancing properties of whole ginseng extracts and single ginsenosides; however, no study to date has determined the receptors that mediate the effects of ginseng extracts. In this study, for the first time, we explored whether the antiinflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE) are mediated by retinoid X receptor α-peroxisome-proliferating receptor γ (RXRα-PPARγ) heterodimer nuclear receptors.

Methods: Nitric oxide assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay, quantitative reverse transcription polymerase chain reaction, nuclear hormone receptor-binding assay, and molecular docking analyses were used for this study.

Results: Rg3-RGE exerted antiinflammatory effects via nuclear receptor heterodimers between RXRα and PPARγ agonists and antagonists.

Conclusion: These findings indicate that Rg3-RGE can be considered a potent antiinflammatory agent, and these effects are likely mediated by the nuclear receptor RXRα-PPARγ heterodimer.

Citing Articles

Modification of Ginseng Insoluble Dietary Fiber by Enzymatic Method: Structural, Rheological, Thermal and Functional Properties.

Jiang G, Ramachandraiah K, Tan C, Cai N, Ameer K, Feng X Foods. 2023; 12(14).

PMID: 37509900 PMC: 10379364. DOI: 10.3390/foods12142809.

Restorative effects of Rg3-enriched Korean Red Ginseng and extract on oxazolone-induced ulcerative colitis in mice.

Ullah H, Saba E, Lee Y, Hong S, Hyun S, Kwak Y J Ginseng Res. 2022; 46(5):628-635.

PMID: 36090686 PMC: 9459072. DOI: 10.1016/j.jgr.2021.07.001.

Rapid Discrimination and Prediction of Ginsengs from Three Origins Based on UHPLC-Q-TOF-MS Combined with SVM.

Zhang C, Liu Z, Lu S, Xiao L, Xue Q, Jin H Molecules. 2022; 27(13).

PMID: 35807471 PMC: 9268438. DOI: 10.3390/molecules27134225.

Extract Ameliorates LPS-Induced Septic Shock in Mice.

Lee Y, Yuk H, Saba E, Kim S, Kim D, Kopalli S Evid Based Complement Alternat Med. 2022; 2022:5783867.

PMID: 35607518 PMC: 9124116. DOI: 10.1155/2022/5783867.

Inhibitory Effect of Extract on CFA-Induced Inflammation in MH-S Cells through Nuclear Factor-B and Mitogen-Activated Protein Kinase Signaling Pathways.

Ullah H, Lee Y, Yun B, Kim S, Rhee M Evid Based Complement Alternat Med. 2021; 2021:5535630.

PMID: 34733341 PMC: 8560242. DOI: 10.1155/2021/5535630.

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