Mesenchymal Stromal Cell Therapy for Damaged Retinal Ganglion Cells, is Gold All That Glitters?

Overview

Journal Neural Regen Res

Date 2019 Jul 11

PMID 31290434

Citations 11

Authors

Fernando Lucas-Ruiz

Caridad Galindo-Romero

David Garcia-Bernal

Maria Norte-Munoz

Kristy T Rodriguez-Ramirez

Manuel Salinas-Navarro

Jose E Millan-Rivero

Manuel Vidal-Sanz

Marta Agudo-Barriuso

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e., Wharton's jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.

Citing Articles

Small extracellular vesicles derived from microRNA-22-3p-overexpressing mesenchymal stem cells protect retinal ganglion cells by regulating MAPK pathway.

Yu B, Wang K, Hao H, Liu Y, Yue Y, Li X Commun Biol. 2024; 7(1):807.

PMID: 38961177 PMC: 11222527. DOI: 10.1038/s42003-024-06511-z.

Suprachoroidal spheroidal mesenchymal stem cell implantation in retinitis pigmentosa: clinical results of 6 months follow-up.

Ozkan B, Yilmaz Tugan B, Hemsinlioglu C, Sir Karakus G, Sahin O, Ovali E Stem Cell Res Ther. 2023; 14(1):252.

PMID: 37705097 PMC: 10500760. DOI: 10.1186/s13287-023-03489-z.

Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation.

Rao M, Huang Y, Liu C, Meadows C, Cheng H, Zhou M Sci Rep. 2023; 13(1):5592.

PMID: 37019993 PMC: 10076364. DOI: 10.1038/s41598-023-32702-5.

Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations.

Garcia-Ayuso D, Di Pierdomenico J, Garcia-Bernal D, Vidal-Sanz M, Villegas-Perez M Neural Regen Res. 2022; 17(9):1937-1944.

PMID: 35142670 PMC: 8848608. DOI: 10.4103/1673-5374.335692.

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies.

Hu Y, Grodzki L, Bartsch S, Bartsch U Biology (Basel). 2021; 10(11).

PMID: 34827174 PMC: 8615038. DOI: 10.3390/biology10111181.

References

Bharti D, Shivakumar S, Park J, Ullah I, Subbarao R, Park J . Comparative analysis of human Wharton's jelly mesenchymal stem cells derived from different parts of the same umbilical cord. Cell Tissue Res. 2017; 372(1):51-65. PMC: 5862947. DOI: 10.1007/s00441-017-2699-4. View

Woodbury D, Schwarz E, Prockop D, Black I . Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 2000; 61(4):364-70. DOI: 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C. View

Wagers A, Weissman I . Plasticity of adult stem cells. Cell. 2004; 116(5):639-48. DOI: 10.1016/s0092-8674(04)00208-9. View

Horwitz E, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini F . Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy. 2005; 7(5):393-5. DOI: 10.1080/14653240500319234. View

Fraser J, Wulur I, Alfonso Z, Hedrick M . Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol. 2006; 24(4):150-4. DOI: 10.1016/j.tibtech.2006.01.010. View

Borgonovo T, Solarewicz M, Vaz I, Daga D, Rebelatto C, Senegaglia A . Emergence of clonal chromosomal alterations during the mesenchymal stromal cell cultivation. Mol Cytogenet. 2015; 8:94. PMC: 4666177. DOI: 10.1186/s13039-015-0197-5. View

Gimble J . Adipose tissue-derived therapeutics. Expert Opin Biol Ther. 2003; 3(5):705-13. DOI: 10.1517/14712598.3.5.705. View

Zuk P, Zhu M, Mizuno H, Huang J, Futrell J, Katz A . Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7(2):211-28. DOI: 10.1089/107632701300062859. View

Miura M, Miura Y, Padilla-Nash H, Molinolo A, Fu B, Patel V . Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells. 2005; 24(4):1095-103. DOI: 10.1634/stemcells.2005-0403. View

10.

Mead B, Tomarev S . Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms. Stem Cells Transl Med. 2017; 6(4):1273-1285. PMC: 5442835. DOI: 10.1002/sctm.16-0428. View

11.

Venkatesh K, Sen D . Mesenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson's Disease. Curr Stem Cell Res Ther. 2016; 12(4):326-347. DOI: 10.2174/1574888X12666161114122059. View

12.

Sanchez-Migallon M, Valiente-Soriano F, Nadal-Nicolas F, Vidal-Sanz M, Agudo-Barriuso M . Apoptotic Retinal Ganglion Cell Death After Optic Nerve Transection or Crush in Mice: Delayed RGC Loss With BDNF or a Caspase 3 Inhibitor. Invest Ophthalmol Vis Sci. 2016; 57(1):81-93. DOI: 10.1167/iovs.15-17841. View

13.

Di Polo A, Aigner L, Dunn R, Bray G, Aguayo A . Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells. Proc Natl Acad Sci U S A. 1998; 95(7):3978-83. PMC: 19948. DOI: 10.1073/pnas.95.7.3978. View

14.

Sommerfeld M, Schweigreiter R, Barde Y, Hoppe E . Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB. J Biol Chem. 2000; 275(12):8982-90. DOI: 10.1074/jbc.275.12.8982. View

15.

Lin Y, Ko T, Shih Y, Lin M, Fu T, Hsiao H . Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. Stroke. 2011; 42(7):2045-53. DOI: 10.1161/STROKEAHA.110.603621. View

16.

Zhou Z, Chen Y, Zhang H, Min S, Yu B, He B . Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury. Cytotherapy. 2013; 15(4):434-48. DOI: 10.1016/j.jcyt.2012.11.015. View

17.

Argentati C, Morena F, Bazzucchi M, Armentano I, Emiliani C, Martino S . Adipose Stem Cell Translational Applications: From Bench-to-Bedside. Int J Mol Sci. 2018; 19(11). PMC: 6275042. DOI: 10.3390/ijms19113475. View

18.

Baksh D, Yao R, Tuan R . Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells. 2007; 25(6):1384-92. DOI: 10.1634/stemcells.2006-0709. View

19.

Subramanian A, Fong C, Biswas A, Bongso A . Comparative Characterization of Cells from the Various Compartments of the Human Umbilical Cord Shows that the Wharton's Jelly Compartment Provides the Best Source of Clinically Utilizable Mesenchymal Stem Cells. PLoS One. 2015; 10(6):e0127992. PMC: 4464659. DOI: 10.1371/journal.pone.0127992. View

20.

Carson C, Aigner S, Gage F . Stem cells: the good, bad and barely in control. Nat Med. 2006; 12(11):1237-8. DOI: 10.1038/nm1106-1237. View