Evaluation of GALNT16 Polymorphisms to Breast Cancer Risk in Chinese Population

Overview

Journal Mol Genet Genomic Med

Specialty Genetics

Date 2019 Jul 10

PMID 31286696

Citations 7

Authors

Huangfu Wu

Guisheng He

Tao Song

Yazhen Zhang

Xiuxiu Chen

Huamin Chen

Wei Xiong

Chuanwei Sun

Chaoyang Zhao

Yunjing Chen

Affiliations

Soon will be listed here.

Abstract

Background: Polypeptide N-acetylgalactosaminyltransferase 16 (GALNT16) is an N-acetylgalactosaminyltransferase gene that alters protein O-glycosylation, which plays a role in tumor development. This study aims to explore the association of eight GALNT16 polymorphisms with susceptibility to breast cancer (BC).

Methods: This case-control study included 563 BC patients and 552 age-matched healthy controls from the Chinese Han population. The genotypes of GALNT16 polymorphisms were detected using the Agena MassARRAY. The relationship between GALNT16 polymorphisms and BC risk was evaluated using a chi-squared test with an odds ratio (OR) and 95% confidence intervals (CI) under five genetic models.

Results: We observed that rs2105269 and rs72625676 were associated with higher BC risk in younger patients with age ≤51 (rs2105269, codominant: p = .006; recessive: p = .005 additive: p = .018; and allele: p = .012; rs72625676, codominant: p = .038; recessive: p = .037). For rs1275678 polymorphism, there was a significantly decreased risk of BC among elder patients (codominant: p = .017; dominant: p = .019; additive: p = .030; and allele: p = .029). Further analysis by clinical characteristics showed rs2105269 was associated with tumor size and lymph node metastasis.

Conclusion: Our study suggests that GALNT16 polymorphisms are associated with BC susceptibility in Chinese population.

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