Circulating Tumor Cells in Diagnosis and Treatment of Lung Cancer

Overview

Journal In Vivo

Specialty Oncology

Date 2019 Jul 8

PMID 31280190

Citations 57

Authors

Vilem Maly

Ondrej Maly

Katarina Kolostova

Vladimir Bobek

Affiliations

Soon will be listed here.

Abstract

Circulating tumor cells (CTCs), detached from the primary tumor or metastases and shed in the patient's bloodstream, represent a relatively easily obtainable sample of the cancer tissue that can indicate the actual state of cancer, and their evaluation can be repeated many times during the course of treatment. As part of liquid biopsy, evaluation of CTCs provides a lot of clinically relevant information, which reflects the actual, real-time conditions of the disease. CTCs can be used in cancer diagnosis or screening, real-time long-term disease monitoring and even therapy guidance. Their analysis can include their number, morphology, and biological features by using immunocytochemistry and all "-omic" technologies. This review describes methods of CTC isolation and potential clinical utilization in lung cancer.

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