Influenza Passaging Annotations: What They Tell Us and Why We Should Listen

Overview

Journal Virus Evol

Publisher Oxford University Press

Date 2019 Jul 6

PMID 31275610

Citations 5

Authors

Cory D DuPai

Claire D McWhite

Catherine B Smith

Rebecca Garten

Sebastian Maurer-Stroh

Claus O Wilke

Affiliations

Soon will be listed here.

Abstract

Influenza databases now contain over 100,000 worldwide sequence records for strains influenza A(H3N2) and A(H1N1). Although these data facilitate global research efforts and vaccine development practices, they also represent a stumbling block for researchers because of their confusing and heterogeneous annotation. Unclear passaging annotations are particularly concerning given the recent work highlighting the presence and risk of false adaptation signals introduced by cell passaging of viral isolates. With this in mind, we aim to provide a concise outline of why viruses are passaged, a clear overview of passaging annotation nomenclature currently in use, and suggestions for a standardized nomenclature going forward. Our hope is that this summary will empower researchers and clinicians alike to more easily understand a virus sample's passage history when analyzing influenza sequences.

Citing Articles

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