In Vivo and in Vitro Alterations in Influenza A/H3N2 Virus M2 and Hemagglutinin Genes: Effect of Passage in MDCK-SIAT1 Cells and Conventional MDCK Cells

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2008 Dec 19

PMID 19091815

Citations 9

Authors

Danjuan Li

Reiko Saito

Yasushi Suzuki

Isamu Sato

Hassan Zaraket

Clyde Dapat

Isolde Ma Caperig-Dapat

Hiroshi Suzuki

Affiliations

Soon will be listed here.

Abstract

No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.

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