Secondary Metabolites Produced by Combined Culture of and a Sp

Overview

Journal J Nat Prod

Date 2019 Jul 3

PMID 31265288

Citations 29

Authors

Guihong Yu

Zichao Sun

Jixing Peng

MeiLin Zhu

Qian Che

Guojian Zhang

Tianjiao Zhu

Qianqun Gu

Dehai Li

Affiliations

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Abstract

Four new alkyl aromatics, penixylarins A-D (-), along with the known biogenetically related 1,3-dihydroxy-5-(12-hydroxyheptadecyl)benzene () and 1,3-dihydroxy-5-(12-sulfoxyheptadecyl)benzene (), were isolated from a mixed culture of the Antarctic deep-sea-derived fungus PRB-2 and the mangrove-derived fungus sp. HDN13-249. UPLC-MS data and an analysis of structural features showed that compounds and were produced by collaboration of the two fungi, while compounds - could be produced by sp. HDN13-249 alone, but in noticeably increased quantities by cocultivation. Compounds , , , and showed antibacterial activity against a panel of strains, and compound possessed potential antituberculosis effects (MIC = 6.25 μM against ).

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