Mendelian Randomization: the Challenge of Unobserved Environmental Confounds

Overview

Journal Int J Epidemiol

Specialty Public Health

Date 2019 Jul 3

PMID 31263889

Citations 32

Authors

Philipp D Koellinger

Ronald de Vlaming

Affiliations

Soon will be listed here.

Citing Articles

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Does Tobacco Smoking Increase Social Isolation? A Mendelian Randomization Study.

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A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss.

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References

Visscher P, Wray N, Zhang Q, Sklar P, McCarthy M, Brown M . 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet. 2017; 101(1):5-22. PMC: 5501872. DOI: 10.1016/j.ajhg.2017.06.005. View

Daetwyler H, Villanueva B, Woolliams J . Accuracy of predicting the genetic risk of disease using a genome-wide approach. PLoS One. 2008; 3(10):e3395. PMC: 2561058. DOI: 10.1371/journal.pone.0003395. View

Kong A, Thorleifsson G, Frigge M, Vilhjalmsson B, Young A, Thorgeirsson T . The nature of nurture: Effects of parental genotypes. Science. 2018; 359(6374):424-428. DOI: 10.1126/science.aan6877. View

Hamer D, Sirota L . Beware the chopsticks gene. Mol Psychiatry. 2000; 5(1):11-3. DOI: 10.1038/sj.mp.4000662. View

Davey Smith G, Ebrahim S . 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?. Int J Epidemiol. 2003; 32(1):1-22. DOI: 10.1093/ije/dyg070. View

Bulik-Sullivan B, Loh P, Finucane H, Ripke S, Yang J, Patterson N . LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015; 47(3):291-5. PMC: 4495769. DOI: 10.1038/ng.3211. View

Zhu Z, Zheng Z, Zhang F, Wu Y, Trzaskowski M, Maier R . Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat Commun. 2018; 9(1):224. PMC: 5768719. DOI: 10.1038/s41467-017-02317-2. View

DiPrete T, Burik C, Koellinger P . Genetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data. Proc Natl Acad Sci U S A. 2018; 115(22):E4970-E4979. PMC: 5984483. DOI: 10.1073/pnas.1707388115. View

Brumpton B, Sanderson E, Heilbron K, Hartwig F, Harrison S, Vie G . Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nat Commun. 2020; 11(1):3519. PMC: 7360778. DOI: 10.1038/s41467-020-17117-4. View

10.

Stringhini S, Carmeli C, Jokela M, Avendano M, Muennig P, Guida F . Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women. Lancet. 2017; 389(10075):1229-1237. PMC: 5368415. DOI: 10.1016/S0140-6736(16)32380-7. View

11.

Davey Smith G, Hemani G . Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014; 23(R1):R89-98. PMC: 4170722. DOI: 10.1093/hmg/ddu328. View

12.

Lawlor D, Harbord R, Sterne J, Timpson N, Davey Smith G . Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2007; 27(8):1133-63. DOI: 10.1002/sim.3034. View

13.

von Hinke Kessler Scholder S, Davey Smith G, Lawlor D, Propper C, Windmeijer F . Mendelian randomization: the use of genes in instrumental variable analyses. Health Econ. 2011; 20(8):893-6. DOI: 10.1002/hec.1746. View

14.

Mills M, Rahal C . A scientometric review of genome-wide association studies. Commun Biol. 2019; 2:9. PMC: 6323052. DOI: 10.1038/s42003-018-0261-x. View

15.

Willett W . Diet and health: what should we eat?. Science. 1994; 264(5158):532-7. DOI: 10.1126/science.8160011. View

16.

Hsia J, Kemper E, Kiefe C, Zapka J, Sofaer S, Pettinger M . The importance of health insurance as a determinant of cancer screening: evidence from the Women's Health Initiative. Prev Med. 2000; 31(3):261-70. DOI: 10.1006/pmed.2000.0697. View

17.

Zheng J, Baird D, Borges M, Bowden J, Hemani G, Haycock P . Recent Developments in Mendelian Randomization Studies. Curr Epidemiol Rep. 2017; 4(4):330-345. PMC: 5711966. DOI: 10.1007/s40471-017-0128-6. View

18.

Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H . The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 2013; 42(Database issue):D1001-6. PMC: 3965119. DOI: 10.1093/nar/gkt1229. View

19.

Hemani G, Bowden J, Davey Smith G . Evaluating the potential role of pleiotropy in Mendelian randomization studies. Hum Mol Genet. 2018; 27(R2):R195-R208. PMC: 6061876. DOI: 10.1093/hmg/ddy163. View

20.

Loh P, Tucker G, Bulik-Sullivan B, Vilhjalmsson B, Finucane H, Salem R . Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat Genet. 2015; 47(3):284-90. PMC: 4342297. DOI: 10.1038/ng.3190. View