Prediction of Titanium Implant Success by Analysis of MicroRNA Expression in Peri-Implant Tissue. A 5-Year Follow-Up Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2019 Jun 26

PMID 31234311

Citations 15

Authors

Maria Menini

Paolo Pesce

Domenico Baldi

Gabriela Coronel Vargas

Paolo Pera

Alberto Izzotti

Affiliations

Soon will be listed here.

Abstract

The aim of the present study is to evaluate the expression of microRNA (miRNA) in peri-implant soft tissue and to correlate epigenetic information with the clinical outcomes of the implants up to the five-year follow-up. Seven patients have been rehabilitated with fixed screw-retained bridges each supported by implants. Peri-implant bone resorption and soft tissue health parameters have been recorded over time with a five-year follow-up. Mini-invasive samples of soft peri-implant tissue have been taken three months after implant insertion. miRNA have been extracted from cells of the soft tissue samples to evaluate gene-expression at the implant sites by microarray analysis. The epigenomic data obtained by microarray technology has been statistically analyzed by dedicated software and compared with measured clinical parameters. Specific miRNA expression profiles predictive of specific clinical outcomes were found. In particular, some specific miRNA signatures appeared to be "protective" from bone resorption despite the presence of plaque accumulation. miRNA may be predictors of dental implant clinical outcomes and may be used as biomarkers for diagnostic and prognostic purposes in the field of implant dentistry.

Citing Articles

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