Tumor Suppressive Effects of the Pleiotropically Acting MiR-195 in Colorectal Cancer Cells

Overview

Journal EXCLI J

Specialty Biology

Date 2019 Jun 21

PMID 31217787

Citations 9

Authors

Zahra Forouzan Jahromi

Arash Javeri

Masoumeh Fakhr Taha

Affiliations

Soon will be listed here.

Abstract

Downregulation of miR-195 in colorectal cancer tissues has been reported in several studies. We investigated the impact exogenous induction of mature miR-195-5p on some malignant features of human colorectal cancer cells. Caco-2 and SW480 human colon cancer cell lines were transfected with a synthetic miR-195-5p mimic. Exogenous induction of miR-195-5p suppressed multiple mediators of invasion and angiogenesis in colorectal cancer cells and increased the apoptotic cell population in both cell lines. Also, migration of both cell lines was significantly compromised after miR-195 transfection. Our results are indicating a strong tumor suppressive role for miR-195 in human colorectal cancer.

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