Functional MRI to Study Gait Impairment in Parkinson's Disease: a Systematic Review and Exploratory ALE Meta-Analysis

Overview

Journal Curr Neurol Neurosci Rep

Specialty Neurology

Date 2019 Jun 20

PMID 31214901

Citations 21

Authors

Moran Gilat

Bauke W Dijkstra

Nicholas DCruz

Alice Nieuwboer

Simon J G Lewis

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Whilst gait impairment is a main cause for disability in Parkinson's disease (PD), its neural control remains poorly understood. We performed a systematic review and meta-analysis of neuroimaging studies of surrogate features of gait in PD.

Findings: Assessing the results from PET or SPECT scans after a period of actual walking as well as fMRI during mental imagery or virtual reality (VR) gait paradigms, we found a varying pattern of gait-related brain activity. Overall, a decrease in activation of the SMA during gait was found in PD compared to elderly controls. In addition, the meta-analysis showed that the most consistent gait-related activation was situated in the cerebellar locomotor region (CLR) in PD. Despite methodological heterogeneity, the combined neuroimaging studies of gait provide new insights into its neural control in PD, suggesting that CLR activation likely serves a compensatory role in locomotion.

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References

Hanakawa T, Fukuyama H, Katsumi Y, Honda M, Shibasaki H . Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease. Ann Neurol. 1999; 45(3):329-36. DOI: 10.1002/1531-8249(199903)45:3<329::aid-ana8>3.0.co;2-s. View

Hanakawa T, Katsumi Y, Fukuyama H, Honda M, Hayashi T, Kimura J . Mechanisms underlying gait disturbance in Parkinson's disease: a single photon emission computed tomography study. Brain. 1999; 122 ( Pt 7):1271-82. DOI: 10.1093/brain/122.7.1271. View

Ouchi Y, Kanno T, Okada H, Yoshikawa E, Futatsubashi M, Nobezawa S . Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. Brain. 2001; 124(Pt 4):784-92. DOI: 10.1093/brain/124.4.784. View

Turkeltaub P, Eden G, Jones K, Zeffiro T . Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage. 2002; 16(3 Pt 1):765-80. DOI: 10.1006/nimg.2002.1131. View

Bloem B, Hausdorff J, Visser J, Giladi N . Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena. Mov Disord. 2004; 19(8):871-84. DOI: 10.1002/mds.20115. View

Morton S, Bastian A . Cerebellar contributions to locomotor adaptations during splitbelt treadmill walking. J Neurosci. 2006; 26(36):9107-16. PMC: 6674518. DOI: 10.1523/JNEUROSCI.2622-06.2006. View

Hausdorff J, Lowenthal J, Herman T, Gruendlinger L, Peretz C, Giladi N . Rhythmic auditory stimulation modulates gait variability in Parkinson's disease. Eur J Neurosci. 2007; 26(8):2369-75. DOI: 10.1111/j.1460-9568.2007.05810.x. View

Shulman L, Gruber-Baldini A, Anderson K, Vaughan C, Reich S, Fishman P . The evolution of disability in Parkinson disease. Mov Disord. 2008; 23(6):790-6. DOI: 10.1002/mds.21879. View

Jacobs J, Nutt J, Carlson-Kuhta P, Stephens M, Horak F . Knee trembling during freezing of gait represents multiple anticipatory postural adjustments. Exp Neurol. 2008; 215(2):334-41. PMC: 3141813. DOI: 10.1016/j.expneurol.2008.10.019. View

10.

Eickhoff S, Laird A, Grefkes C, Wang L, Zilles K, Fox P . Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp. 2009; 30(9):2907-26. PMC: 2872071. DOI: 10.1002/hbm.20718. View

11.

Gilman S, Koeppe R, Nan B, Wang C, Wang X, Junck L . Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes. Neurology. 2010; 74(18):1416-23. PMC: 2871002. DOI: 10.1212/WNL.0b013e3181dc1a55. View

12.

Kerr G, Worringham C, Cole M, Lacherez P, Wood J, Silburn P . Predictors of future falls in Parkinson disease. Neurology. 2010; 75(2):116-24. DOI: 10.1212/WNL.0b013e3181e7b688. View

13.

Snijders A, Leunissen I, Bakker M, Overeem S, Helmich R, Bloem B . Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait. Brain. 2010; 134(Pt 1):59-72. DOI: 10.1093/brain/awq324. View

14.

Nutt J, Bloem B, Giladi N, Hallett M, Horak F, Nieuwboer A . Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol. 2011; 10(8):734-44. PMC: 7293393. DOI: 10.1016/S1474-4422(11)70143-0. View

15.

Eickhoff S, Bzdok D, Laird A, Kurth F, Fox P . Activation likelihood estimation meta-analysis revisited. Neuroimage. 2011; 59(3):2349-61. PMC: 3254820. DOI: 10.1016/j.neuroimage.2011.09.017. View

16.

Maillet A, Pollak P, Debu B . Imaging gait disorders in parkinsonism: a review. J Neurol Neurosurg Psychiatry. 2012; 83(10):986-93. DOI: 10.1136/jnnp-2012-302461. View

17.

Cremers J, DOstilio K, Stamatakis J, Delvaux V, Garraux G . Brain activation pattern related to gait disturbances in Parkinson's disease. Mov Disord. 2012; 27(12):1498-505. DOI: 10.1002/mds.25139. View

18.

Wu T, Hallett M . The cerebellum in Parkinson's disease. Brain. 2013; 136(Pt 3):696-709. PMC: 7273201. DOI: 10.1093/brain/aws360. View

19.

Shine J, Matar E, Ward P, Bolitho S, Gilat M, Pearson M . Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson's disease. Brain. 2013; 136(Pt 4):1204-15. DOI: 10.1093/brain/awt049. View

20.

Allen N, Schwarzel A, Canning C . Recurrent falls in Parkinson's disease: a systematic review. Parkinsons Dis. 2013; 2013:906274. PMC: 3606768. DOI: 10.1155/2013/906274. View