Sjogren's Syndrome and TAM Receptors: A Possible Contribution to Disease Onset

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2019 Jun 20

PMID 31214622

Citations 10

Authors

Richard Witas

Ammon B Peck

Julian L Ambrus

Cuong Q Nguyen

Affiliations

Soon will be listed here.

Abstract

Sjogren's syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands. Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature. Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling. This review examines the relationship between TAM receptor dysfunction and SS and explores the potential contributions of TAM defects on macrophages to SS development.

Citing Articles

Sjögren's Disease and Gastroesophageal Reflux Disease: What Is Their Evidence-Based Link?.

Mieliauskaite D, Kontenis V Medicina (Kaunas). 2024; 60(11).

PMID: 39597079 PMC: 11596513. DOI: 10.3390/medicina60111894.

Advances in cellular and molecular pathways of salivary gland damage in Sjögren's syndrome.

Qi W, Tian J, Wang G, Yan Y, Wang T, Wei Y Front Immunol. 2024; 15:1405126.

PMID: 39050857 PMC: 11266040. DOI: 10.3389/fimmu.2024.1405126.

Abnormal expression of CXCL13, MIF and IL-35 in patients with primary Sjögren's syndrome and its relationship with disease severity.

Wang R, Yang Y, Liu X, Lei L, Qi X Cent Eur J Immunol. 2023; 48(2):144-149.

PMID: 37692029 PMC: 10485687. DOI: 10.5114/ceji.2023.127536.

Analysis of the saliva metabolic signature in patients with primary Sjögren's syndrome.

Li Z, Mu Y, Guo C, You X, Liu X, Li Q PLoS One. 2022; 17(6):e0269275.

PMID: 35653354 PMC: 9162338. DOI: 10.1371/journal.pone.0269275.

Bone marrow-derived macrophages from a murine model of Sjögren's syndrome demonstrate an aberrant, inflammatory response to apoptotic cells.

Witas R, Shen Y, Nguyen C Sci Rep. 2022; 12(1):8593.

PMID: 35597820 PMC: 9124194. DOI: 10.1038/s41598-022-12608-4.

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