Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

Overview

Journal Front Oncol

Specialty Oncology

Date 2019 Jun 20

PMID 31214487

Citations 19

Authors

Xiangyi Kong

Jie Zhai

Chengrui Yan

Yan Song

Jing Wang

Xiaofeng Bai

James A L Brown

Yi Fang

Affiliations

Soon will be listed here.

Abstract

FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.

Citing Articles

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The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.

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FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.

Yang H, Li M, Qi Y Hum Cell. 2023; 36(3):1120-1134.

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