MicroRNA-224, Negatively Regulated by C-jun, Inhibits Growth and Epithelial-to-mesenchymal Transition Phenotype Via Targeting ADAM17 in Oral Squamous Cell Carcinoma

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2019 Jun 18

PMID 31207072

Citations 12

Authors

Yaoyong Lu

Wendong Huang

Haiwen Chen

Huajun Wei

Aihua Luo

Guangsheng Xia

Xubin Deng

Gong Zhang

Affiliations

Soon will be listed here.

Abstract

Abnormal expression of miR-224 has been reported to promote cancer progression. However, the role of miR-224 is seldom reported in oral squamous cell carcinoma (OSCC). We reported that miR-224 expression was significantly down-regulated in OSCC tissues and cell lines. Restoration of miR-224 decreased OSCC cell growth and invasion. In addition, luciferase and Western blot assays revealed that ADAM17 protein was a downstream target of miR-224. The overexpression of ADAM17 dismissed miR-224's effect on cell growth and invasion. We concluded that miR-224 inhibited OSCC cell growth and invasion through regulating ADAM17 expression. Subsequently, we revealed that c-jun directly bind to miR-224 promoter and decreased miR-224 expression. Taken together, these findings demonstrated that miR-224 may function as a tumour-suppressive microRNA in OSCC and suggested that miR-224 may be a potential therapeutic target for OSCC patients.

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