Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 Jun 18

PMID 31205933

Citations 14

Authors

Yinghao Yu

Jijun Zhao

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage regression. The etiology of OA is diverse, the exact pathogenesis of which remains unclear. Autophagy is a conserved maintenance mechanism in eukaryotic cells. Dysfunction of chondrocyte autophagy is regarded as a crucial pathogenesis of cartilage degradation in OA. MircoRNAs (miRNAs) are a category of small noncoding RNAs, acting as posttranscriptional modulators that regulate biological processes and cell signaling pathways via target genes. A series of miRNAs are involved in the progression of chondrocyte autophagy and are connected with numerous factors and pathways. This article focuses on the mechanisms of chondrocyte autophagy in OA and reviews the role of miRNA in their modulation. Potentially relevant miRNAs are also discussed in order to provide new directions for future research and improve our understanding of the autophagic network of miRNAs.

Citing Articles

Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes.

Yu Q, Xiao Y, Guan M, Zhou G, Zhang X, Yu J Front Med (Lausanne). 2024; 11:1478153.

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Promotion and Mechanism of Acupotomy on Chondrocyte Autophagy in Knee Osteoarthritis Rabbits.

Lu M, Meng D, She Z, Wu X, Xia S, Yang K Chin J Integr Med. 2024; 30(9):809-817.

PMID: 38900226 DOI: 10.1007/s11655-024-3759-8.

The Role of Autophagy in Osteoarthritic Cartilage.

Kao W, Chen J, Liu P, Lu C, Lin S, Chuang S Biomolecules. 2022; 12(10).

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Strain-Specific Behavior of Mycobacterium tuberculosis in Interruption of Autophagy Pathway in Human Alveolar Type II Epithelial A549 Cells.

Ebrahimifard N, Hadifar S, Kamakoli M, Behrouzi A, Khanipour S, Fateh A Iran Biomed J. 2022; 26(4):313-23.

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LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis.

Li H, Lian K, Mao J, Huang F, Zhang C, Zang J Cell Cycle. 2022; 21(19):2038-2050.

PMID: 35686740 PMC: 9467614. DOI: 10.1080/15384101.2022.2084294.

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