Effects of Restraint Stress on the Regulation of Hippocampal Glutamate Receptor and Inflammation Genes in Female C57BL/6 and BALB/c Mice

Overview

Journal Neurobiol Stress

Date 2019 Jun 14

PMID 31193545

Citations 6

Authors

Joshua McWhirt

Monica Sathyanesan

Dayalan Sampath

Samuel S Newton

Affiliations

Soon will be listed here.

Abstract

The two strains of inbred mice, BALB/c and C57BL/6, are widely used in pre-clinical psychiatry research due to their differences in stress susceptibility. Gene profiling studies in these strains have implicated the inflammation pathway as the main contributor to these differences. We focused our attention on female mice and tested their response to 5- or 10-day exposure to restraint stress. We examined the stress induced changes in the regulation of 11 inflammatory cytokine genes and 12 glutamate receptor genes in the hippocampus of female BALB/c and C57BL/6 mice using quantitative PCR. Elevated proinflammatory cytokine genes include Tumor Necrosis Factor alpha (TNFa), nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB), Interleukin 1 alpha (IL1a), Interleukin 1 receptor (IL1R), Interleukin 10 receptor alpha subunit (IL10Ra), Interleukin 10 receptor beta subunit (IL10Rb), and tumor necrosis factor (TNF) super family members. Our results show that BALB/c and C57BL/6 mice differ in the genes induced in response to stress exposure and the level of gene regulation change. Our results show that the gene regulation in female BALB/c and C57BL/6 mice differs between strains in the genes regulated and the magnitude of the changes.

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References

Kornstein S, Schatzberg A, Thase M, Yonkers K, McCullough J, Keitner G . Gender differences in chronic major and double depression. J Affect Disord. 2000; 60(1):1-11. DOI: 10.1016/s0165-0327(99)00158-5. View

Flint M, Tinkle S . C57BL/6 mice are resistant to acute restraint modulation of cutaneous hypersensitivity. Toxicol Sci. 2001; 62(2):250-6. DOI: 10.1093/toxsci/62.2.250. View

Snyder E, Philpot B, Huber K, Dong X, Fallon J, Bear M . Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat Neurosci. 2001; 4(11):1079-85. DOI: 10.1038/nn746. View

Burt V, Stein K . Epidemiology of depression throughout the female life cycle. J Clin Psychiatry. 2002; 63 Suppl 7:9-15. View

Newton S, Collier E, Hunsberger J, Adams D, Terwilliger R, Selvanayagam E . Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. J Neurosci. 2003; 23(34):10841-51. PMC: 6740983. View

Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel U . Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B.... J Biol Chem. 2004; 279(31):32869-81. DOI: 10.1074/jbc.M311766200. View

Pittenger C, Sanacora G, Krystal J . The NMDA receptor as a therapeutic target in major depressive disorder. CNS Neurol Disord Drug Targets. 2007; 6(2):101-15. DOI: 10.2174/187152707780363267. View

Mesquita A, Correia-Neves M, Roque S, Castro A, Vieira P, Pedrosa J . IL-10 modulates depressive-like behavior. J Psychiatr Res. 2008; 43(2):89-97. DOI: 10.1016/j.jpsychires.2008.02.004. View

Verstrepen L, Bekaert T, Chau T, Tavernier J, Chariot A, Beyaert R . TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci. 2008; 65(19):2964-78. PMC: 11131687. DOI: 10.1007/s00018-008-8064-8. View

10.

Grissom N, Bhatnagar S . Habituation to repeated stress: get used to it. Neurobiol Learn Mem. 2008; 92(2):215-24. PMC: 2773683. DOI: 10.1016/j.nlm.2008.07.001. View

11.

Feyissa A, Chandran A, Stockmeier C, Karolewicz B . Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 33(1):70-5. PMC: 2655629. DOI: 10.1016/j.pnpbp.2008.10.005. View

12.

Caligioni C . Assessing reproductive status/stages in mice. Curr Protoc Neurosci. 2009; Appendix 4:Appendix 4I. PMC: 2755182. DOI: 10.1002/0471142301.nsa04is48. View

13.

Deschwanden A, Karolewicz B, Feyissa A, Treyer V, Ametamey S, Johayem A . Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am J Psychiatry. 2011; 168(7):727-34. PMC: 3129412. DOI: 10.1176/appi.ajp.2011.09111607. View

14.

Byers S, Wiles M, Dunn S, Taft R . Mouse estrous cycle identification tool and images. PLoS One. 2012; 7(4):e35538. PMC: 3325956. DOI: 10.1371/journal.pone.0035538. View

15.

Fagundes C, Glaser R, Hwang B, Malarkey W, Kiecolt-Glaser J . Depressive symptoms enhance stress-induced inflammatory responses. Brain Behav Immun. 2012; 31:172-6. PMC: 3518610. DOI: 10.1016/j.bbi.2012.05.006. View

16.

Calabrese F, Guidotti G, Molteni R, Racagni G, Mancini M, Riva M . Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment. PLoS One. 2012; 7(5):e37916. PMC: 3362535. DOI: 10.1371/journal.pone.0037916. View

17.

Vogelzangs N, Duivis H, Beekman A, Kluft C, Neuteboom J, Hoogendijk W . Association of depressive disorders, depression characteristics and antidepressant medication with inflammation. Transl Psychiatry. 2012; 2:e79. PMC: 3309556. DOI: 10.1038/tp.2012.8. View

18.

Raison C, Rutherford R, Woolwine B, Shuo C, Schettler P, Drake D . A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2012; 70(1):31-41. PMC: 4015348. DOI: 10.1001/2013.jamapsychiatry.4. View

19.

GRAY J, Rubin T, Hunter R, McEwen B . Hippocampal gene expression changes underlying stress sensitization and recovery. Mol Psychiatry. 2013; 19(11):1171-8. PMC: 4061278. DOI: 10.1038/mp.2013.175. View

20.

Slavich G, Irwin M . From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014; 140(3):774-815. PMC: 4006295. DOI: 10.1037/a0035302. View