The Inflammatory Response After Ischemic Stroke: Targeting β and β Integrins

Overview

Journal Front Neurosci

Date 2019 Jun 14

PMID 31191232

Citations 18

Authors

Danielle N Edwards

Gregory J Bix

Affiliations

Soon will be listed here.

Abstract

Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the area of ischemia. In particular, leukocytes migrate toward areas of inflammation by use of integrins, particularly integrins β and β. Integrins have been shown to be necessary for leukocyte adhesion and migration, and thus are of immediate interest in many inflammatory diseases, including ischemic stroke. In this review, we identify the main integrins involved in leukocytic migration following stroke (α β, αβ, αβ, and αβ) and targeted clinical therapeutic interventions.

Citing Articles

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