Leukocyte Integrins and Their Ligand Interactions

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2009 Feb 3

PMID 19184539

Citations 35

Authors

Young-Min Hyun

Craig T Lefort

Minsoo Kim

Affiliations

Soon will be listed here.

Abstract

Although critical for cell adhesion and migration during normal immune-mediated reactions, leukocyte integrins are also involved in the pathogenesis of diverse clinical conditions including autoimmune diseases and chronic inflammation. Leukocyte integrins therefore have been targets for anti-adhesive therapies to treat the inflammatory disorders. Recently, the therapeutic potential of integrin antagonists has been demonstrated in psoriasis and multiple sclerosis. However, current therapeutics broadly affect integrin functions and, thus, yield unfavorable side effects. This review discusses the major leukocyte integrins and the anti-adhesion strategies for treating immune diseases.

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