Chondrocyte-derived Cells and Matrix at the Rheumatoid Cartilage-pannus Junction Identified with Monoclonal Antibodies

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1987 Jan 1

PMID 3118444

Citations 11

Authors

S A Allard

K D Muirden

K L Camplejohn

R N Maini

Affiliations

Soon will be listed here.

Abstract

In the cartilage-pannus junction of 14 patients with rheumatoid arthritis (RA) and seven patients with osteoarthritis (OA), monoclonal antibodies to keratan sulphate (KS) and chondroitin sulphate (CS) stained a transitional fibroblastic zone (TFZ) within the pannus in nine RA patients and one OA patient. In three patients this was clearly localised to the cytoplasm of cells in this zone, but in all remaining cases KS and CS could be demonstrated in the surrounding matrix. This area was distinguished from adjacent pannus which contained many blood vessels and cells positive for MHC Class II antigen. Specific markers for glycosaminoglycans have been employed to demonstrate that chondrocyte-derived cells and matrix contribute to the changes seen at the cartilage-pannus junction in RA-affected joints.

Citing Articles

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References

BARRIE H . Histologic changes in rheumatoid disease of the metacarpal and metatarsal heads as seen in surgical material. J Rheumatol. 1981; 8(2):246-57. View

Harris Jr E . Recent insights into the pathogenesis of the proliferative lesion in rheumatoid arthritis. Arthritis Rheum. 1976; 19(1):68-72. DOI: 10.1002/art.1780190111. View

Shiozawa S, Shiozawa K, Fujita T . Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum. 1983; 26(4):472-8. DOI: 10.1002/art.1780260404. View

ROPES M, BENNETT G, COBB S, JACOX R, JESSAR R . 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958; 9(4):175-6. View

Mills K . Pathology of the knee joint in rheumatoid arthritis. A contribution to the understanding of synovectomy. J Bone Joint Surg Br. 1970; 52(4):746-56. View

Papadimitriou C, STEIN H, PAPACHARALAMPOUS N . Presence of alpha1-antichymotrypsin and alpha1-antitrypsin in haematopoietic and lymphoid tissue cells as revealed by the immunoperoxidase method. Pathol Res Pract. 1980; 169(3-4):287-97. DOI: 10.1016/s0344-0338(80)80007-0. View

Mitrovic D . The mechanism of cartilage destruction in rheumatoid arthritis. Arthritis Rheum. 1985; 28(10):1192-5. DOI: 10.1002/art.1780281020. View

Klareskog L, Johnell O, Hulth A . Expression of HLA-DR and HLA-DQ antigens on cells within the cartilage-pannus junction in rheumatoid arthritis. Rheumatol Int. 1984; 4 Suppl:11-5. DOI: 10.1007/BF00541273. View

Muirden K . Electron microscopic studies of the synovial-cartilage junction in rheumatoid arthritis. Eur J Rheumatol Inflamm. 1982; 5(1):30-8. View

10.

Cooke T . Rheumatoid arthritis pannus: true or false?. Arthritis Rheum. 1985; 28(10):1195-8. DOI: 10.1002/art.1780281021. View

11.

Couchman J, Caterson B, CHRISTNER J, Baker J . Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues. Nature. 1984; 307(5952):650-2. DOI: 10.1038/307650a0. View

12.

Bromley M, Woolley D . Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion. Arthritis Rheum. 1984; 27(8):857-63. DOI: 10.1002/art.1780270804. View

13.

Tateishi H . Ultrastructure of synovio-cartilage junction in rheumatoid arthritis. Kobe J Med Sci. 1973; 19(2):51-66. View

14.

Stefansson K, Wollmann R, Moore B, Arnason B . S-100 protein in human chondrocytes. Nature. 1982; 295(5844):63-4. DOI: 10.1038/295063a0. View

15.

Mohr W, Kuhn C, Pelster B, Wessinghage D . S-100 protein in normal, osteoarthrotic, and arthritic cartilage. Rheumatol Int. 1985; 5(6):273-7. DOI: 10.1007/BF00541355. View

16.

Burmester G, Menche D, Merryman P, Klein M, Winchester R . Application of monoclonal antibodies to the characterization of cells eluted from human articular cartilage. Expression of Ia antigens in certain diseases and identification of an 85-kD cell surface molecule accumulated in the pericellular matrix. Arthritis Rheum. 1983; 26(10):1187-95. DOI: 10.1002/art.1780261003. View

17.

McKenzie J, Fabre J . Human thy-1: unusual localization and possible functional significance in lymphoid tissues. J Immunol. 1981; 126(3):843-50. View

18.

Zanetti M, Ratcliffe A, Watt F . Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate. J Cell Biol. 1985; 101(1):53-9. PMC: 2113621. DOI: 10.1083/jcb.101.1.53. View

19.

ZIFF M . Factors involved in cartilage injury. J Rheumatol Suppl. 1983; 11:13-25. View

20.

Kobayashi I, ZIFF M . Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 1975; 18(5):475-83. DOI: 10.1002/art.1780180507. View