Transforming Growth Factor-beta 1 in Rheumatoid Synovial Membrane and Cartilage/pannus Junction

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1991 Dec 1

PMID 1747946

Citations 24

Authors

C Q Chu

M Field

E Abney

R Q Zheng

S Allard

M Feldmann

R N Maini

Affiliations

Soon will be listed here.

Abstract

Transforming growth factor (TGF)-beta has been shown to promote tissue repair and have immunosuppressive actions, and has been proposed to have a role in rheumatoid arthritis (RA). Using immunohistochemical techniques with rabbit F(ab')2 antibodies raised against recombinant human TGF-beta 1, we have detected TGF-beta 1 in the synovial tissue and cartilage/pannus junction (CPJ) from 18/18 patients with RA. TGF-beta 1 was found predominantly in the thickened synovial lining layer in RA, but also detected in a perivascular pattern in the synovial interstitium as well as in occasional cells in the lymphoid aggregates. At the CPJ it was found both in cells at the distinct junction as well as in the transitional region of the diffuse fibroblastic zone. The cells staining for TGF-beta 1 were identified by double immunofluorescence staining as being from the monocyte/macrophage series as well as the type B synovial lining cells. TGF-beta 1 was also detected in the synovial membrane sections from 4/4 patients with systemic lupus erythematosus/mixed connective tissue disease and 5/8 patients with osteoarthritis, in a similar distribution to that seen in RA, and in the lining layer of 1/7 normal synovial membranes. These results add to histological evidence confirming that TGF-beta 1 is present in RA synovial cells and those from other arthritides. The distributions of TGF-beta 1 in RA synovial membrane reflects its known actions, as it can be detected at the CPJ, where it could induce repair, and close to activated cells upon which it may exert an immunosuppressive action.

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References

Roberts A, Sporn M, Assoian R, Smith J, Roche N, Wakefield L . Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986; 83(12):4167-71. PMC: 323692. DOI: 10.1073/pnas.83.12.4167. View

Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31(3):315-24. DOI: 10.1002/art.1780310302. View

Kehrl J, Roberts A, Wakefield L, Jakowlew S, Sporn M, Fauci A . Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes. J Immunol. 1986; 137(12):3855-60. View

Czarniecki C, Chiu H, Wong G, McCabe S, Palladino M . Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells. J Immunol. 1988; 140(12):4217-23. View

Allard S, Muirden K, Camplejohn K, Maini R . Chondrocyte-derived cells and matrix at the rheumatoid cartilage-pannus junction identified with monoclonal antibodies. Rheumatol Int. 1987; 7(4):153-9. DOI: 10.1007/BF00270363. View

Espevik T, Figari I, Shalaby M, Lackides G, Lewis G, Shepard H . Inhibition of cytokine production by cyclosporin A and transforming growth factor beta. J Exp Med. 1987; 166(2):571-6. PMC: 2189589. DOI: 10.1084/jem.166.2.571. View

Wahl S, McCartney-Francis N, Mergenhagen S . Inflammatory and immunomodulatory roles of TGF-beta. Immunol Today. 1989; 10(8):258-61. DOI: 10.1016/0167-5699(89)90136-9. View

Kelly P, Bliss E, MORTON J, Burns J, Mcgee J . Monoclonal antibody EBM/11: high cellular specificity for human macrophages. J Clin Pathol. 1988; 41(5):510-5. PMC: 1141502. DOI: 10.1136/jcp.41.5.510. View

Chantry D, Turner M, Abney E, Feldmann M . Modulation of cytokine production by transforming growth factor-beta. J Immunol. 1989; 142(12):4295-300. View

10.

Shinmei M, Masuda K, Kikuchi T, Shimomura Y . Interleukin 1, tumor necrosis factor, and interleukin 6 as mediators of cartilage destruction. Semin Arthritis Rheum. 1989; 18(3 Suppl 1):27-32. DOI: 10.1016/0049-0172(89)90081-4. View

11.

Grubeck-Loebenstein B, Buchan G, Chantry D, Turner M, Londei M, Feldmann M . Intrathyroidal cytokine production in thyroid disease. J Autoimmun. 1989; 2 Suppl:171-6. DOI: 10.1016/0896-8411(89)90128-5. View

12.

Lafyatis R, Thompson N, Remmers E, Flanders K, Roche N, Kim S . Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization. J Immunol. 1989; 143(4):1142-8. View

13.

Coffman R, Lebman D, Shrader B . Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med. 1989; 170(3):1039-44. PMC: 2189449. DOI: 10.1084/jem.170.3.1039. View

14.

Fava R, Olsen N, Keski-Oja J, MOSES H, Pincus T . Active and latent forms of transforming growth factor beta activity in synovial effusions. J Exp Med. 1989; 169(1):291-6. PMC: 2189180. DOI: 10.1084/jem.169.1.291. View

15.

Poulter L, Campbell D, Munro C, Janossy G . Discrimination of human macrophages and dendritic cells by means of monoclonal antibodies. Scand J Immunol. 1986; 24(3):351-7. DOI: 10.1111/j.1365-3083.1986.tb02104.x. View

16.

Raghow R, Postlethwaite A, Keski-Oja J, Moses H, Kang A . Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest. 1987; 79(4):1285-8. PMC: 424335. DOI: 10.1172/JCI112950. View

17.

Wilder R, Lafyatis R, Roberts A, Case J, Kumkumian G, Sano H . Transforming growth factor-beta in rheumatoid arthritis. Ann N Y Acad Sci. 1990; 593:197-207. DOI: 10.1111/j.1749-6632.1990.tb16112.x. View

18.

Guerne P, Carson D, Lotz M . IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol. 1990; 144(2):499-505. View

19.

Brennan F, Chantry D, Turner M, Foxwell B, Maini R, Feldmann M . Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures. Clin Exp Immunol. 1990; 81(2):278-85. PMC: 1535061. DOI: 10.1111/j.1365-2249.1990.tb03331.x. View

20.

Soriano E, Catoggio L . Baker's cysts, pseudothrombophlebitis, pseudo-pseudothrombophlebitis: where do we stand?. Clin Exp Rheumatol. 1990; 8(2):107-12. View