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Natural Hypothalamic Circuit Dynamics Underlying Object Memorization

Overview
Journal Nat Commun
Specialty Biology
Date 2019 Jun 9
PMID 31175285
Citations 31
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Abstract

Brain signals that govern memory formation remain incompletely identified. The hypothalamus is implicated in memory disorders, but how its rapidly changing activity shapes memorization is unknown. During encounters with objects, hypothalamic melanin-concentrating hormone (MCH) neurons emit brief signals that reflect object novelty. Here we show that targeted optogenetic silencing of these signals, performed selectively during the initial object encounters (i.e. memory acquisition), prevents future recognition of the objects. We identify an upstream inhibitory microcircuit from hypothalamic GAD65 neurons to MCH neurons, which constrains the memory-promoting MCH cell bursts. Finally, we demonstrate that silencing the GAD65 cells during object memory acquisition improves future object recognition through MCH-receptor-dependent pathways. These results provide causal evidence that object-associated signals in genetically distinct but interconnected hypothalamic neurons differentially control whether the brain forms object memories. This gating of memory formation by hypothalamic activity establishes appropriate behavioral responses to novel and familiar objects.

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References
1.
Saper C, German D . Hypothalamic pathology in Alzheimer's disease. Neurosci Lett. 1987; 74(3):364-70. DOI: 10.1016/0304-3940(87)90325-9. View

2.
Pachoud B, Adamantidis A, Ravassard P, Luppi P, Grisar T, Lakaye B . Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1. J Neurophysiol. 2010; 104(3):1417-25. PMC: 4073994. DOI: 10.1152/jn.01052.2009. View

3.
Schwartz M, Teitelbaum P . Dissociation between learning and remembering in rats with lesions in the lateral hypothalamus. J Comp Physiol Psychol. 1974; 87(3):384-98. DOI: 10.1037/h0036976. View

4.
Hausen A, Ruud J, Jiang H, Hess S, Varbanov H, Kloppenburg P . Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. Cell Rep. 2016; 17(10):2512-2521. DOI: 10.1016/j.celrep.2016.11.030. View

5.
Bittencourt J . Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain. Gen Comp Endocrinol. 2011; 172(2):185-97. DOI: 10.1016/j.ygcen.2011.03.028. View